32.Crosstalk between intestinal microbiota, adipose tissue and skeletal muscle as an early event in systemic low-grade inflammation and the development of obesity and diabetes

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1、DIABETES/METABOLISMRESEARCHANDREVIEWSREVIEWARTICLEDiabetesMetabResRev2015;31:545–561Publishedonline8December2014inWileyOnlineLibrary(wileyonlinelibrary.com)DOI:10.1002/dmrr.2617Crosstalkbetweenintestinalmicrobiota,adiposetissueandskeletalmuscleasanearlyeventinsystemi

2、clow-gradeinflammationandthedevelopmentofobesityanddiabetes1ChristianBleauSummary2*AntonyD.Karelis2DavidH.St-PierreObesityisassociatedwithasystemicchroniclow-gradeinflammationthatcon-LucieLamontagne1tributestothedevelopmentofmetabolicdisorderssuchascardiovasculardiseas

3、esandtype2diabetes.However,theetiologyofthisobesity-related1DepartmentofBiologicalSciences,pro-inflammatoryprocessremainsunclear.Moststudieshavefocusedonadi-UniversitéduQuébecàMontréal,posetissuedysfunctionsand/orinsulinresistanceinskeletalmusclecellsasMontreal,Canada

4、,H3C3P8wellaschangesinadipokineprofileandmacrophagerecruitmentaspotential2DepartmentofKinanthropology,sourcesofinflammation.However,low-gradesystemicinflammationprobablyUniversitéduQuébecàMontréal,involvesacomplexnetworkofsignalsinterconnectingseveralorgans.RecentMontre

5、al,Canada,H3C3P8evidenceshavesuggestedthatdisturbancesinthecompositionofthegutmicrobialfloraandalterationsinlevelsofgutpeptidesfollowingtheingestion*Correspondenceto:AntonyKarelis,ofahigh-fatdietmaybeacauseoflow-gradesystemicinflammationthatmayDepartmentofKinanthropolo

6、gy,evenprecedeandpredisposetoobesity,metabolicdisordersortype2diabetes.UniversitéduQuébecàMontréal,C.ThishypothesisisappealingbecausethegastrointestinalsystemisfirstexposedP.8888,SuccursaleCentre-ville,tonutrientsandmaytherebyrepresentthefirstlinkinthechainofeventslead

7、ingMontreal,Quebec,Canada,H3C3P8.E-mail:karelis.antony@uqam.catothedevelopmentofobesity-associatedsystemicinflammation.Therefore,thepresentreviewwillsummarizethelatestadvancesinterconnectingintestinalmucosalbacteria-mediatedinflammation,adiposetissueandskeletalmusclein

8、acoordinatedcircuitryfavouringtheonsetofahigh-fatdiet-relatedsystemiclow-gradeinflammationprecedingobesityandpredisposingtometabolic