资源描述：
《relationship between diabetes mellitus and obesity in the child》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、RelationshipBetweenDiabetesMellitusandObesityintheChildByAllanDrashEighteengrosslyobeseadolescentsever,thoseobesesubjectswithcarbo-havebeeninvestigatedduringa30-hydrateintoleranceachievedpeakin-dayperiodofhospitalization.Sevensulinlevelssignificantlybelowt
2、hosewerefoundtohaveasymptomatic,withnormalcarbohydratetolerance.mild-to-moderatecarbohydrateintoler-Growthhormoneresponsetoarginineanceasdefinedbyresponsetooralinfusionwassignificantlybelowthatglucoseadministration.Allsubjectsofsexuallymature,normalweights
3、ub-demonstratedmarkedhyperinsulinismjects.Weightlosswasreadilyachievedinresponsetoisletcellstimulantsinthehospitalduringcaloricreduc-(glucose,glucagon,andarginine),tionbutnotonanoutpatientbasis.whencomparedwithchildrenandNosubjectshaveprogressedtoovertadol
4、escentsofnormalweight.How-diabetes.THERELATIONSHIPbetweencarbohydrateintoleranceandobesityintheadultpopulationiswelldocumented.Itisestimatedthatapproximately80%ofpatientswithmaturity-onsetdiabetesmellitusareobese,andap-proximately60%ofgrosslyobeseadultshav
5、eevidenceofcarbohydrateintolerance.1-3Itisnotclearthatdiabetesassociatedwithaccumulationofexcessiveweightisrelatedtothegeneticdiseaseofdiabetesasitoccursinthechildorinthenonobeseadult.However,thehighincidenceofcardiovascularanddegenerativecomplicationsoccu
6、rringinobesepatientswithcarbohydratein-tolerance,whethertheintoleranceisprimaryorsecondary,suggeststhatthemetabolicalterationsmaybecausative.Inaddition,reductioninbodyweightisusuallyassociatedwithimprovementincarbohydratetoleranceandimprove-mentin.morbidit
7、yandmortalitystatistics.Therehavebeenfewstudiesonthestatusofcarbohydratetoleranceinthechildwithobesity.Intworecentstudies,chemicaldiabeteswasobservedin15%and25%ofgrosslyobese,preadolescentchildren.4z5Wearecurrentlystudyingthemetabolicalterationsofobesityin
8、theadolescent.FromfheClinicalStudyCenterundThePediufricDiabetesClinic,TheChiIdren’sHospitnlofPittsbztrgh,DepartmentofPediufrics,UniversityofPittsburghSchooIofMedicine,Pittsburgh,Pn.PresentedattheConferenceonC
