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1、ORIGINALARTICLEbesityisariskfactorforNIDDMinFamilyHistoryofDiabetesinbothmenandwomen(1-3).Fur-Othermore,subjectswithafamilyRelationtoDifferentTypesofhistoryofdiabetesareoverrepresentedamongthosewhodevelopNIDDM(4—ObesityandChangeofObesity6).Obesityandfamilyhistoryofdiabeteshaveb
2、eenshowntopresentindependentDuring12-YrPeriodrisksofdiabetesinwomen(6,7).Inthispaper,werelatedfamilyhistoryofdia-Resultsfromprospectivepopulationstudyofbetestoobesityandchangeofobesity.WedefinedobesityasbothgeneralandwomeninGoteborg,Swedenabdominalobesity.RESEARCHDESIGNANDLEIFL
3、^PIDUS,MDLAURENLISSNER,PHDMETHODS—From1968to1969,weCALLEBENGTSSON,MDULFSMITH,MDstudied1462womeninGoteborg,Swe-den,aged38,46,50,54,or60yr.Table1showsthenumberofparticipantsinOBJECTIVE—Toassesstherelationshipbetweenfamilyhistoryanddifferenttypestheinitialexamination.Thepopulation
4、ofobesityandchangeinobesityinalongitudinalpopulationstudy.samplewasfollowedupontwoocca-sions,in1974-1975and1980-1981.RESEARCHDESIGNANDMETHODS—AlongitudinalpopulationstudyofOfthoseparticipatingin1968-1969,1462randomlyselectedwomen(38-60yrold)wasconductedinGoteborg,Sweden,1154(78
5、.9%)tookpartin1980-1981.in1968-69.Thewomenwererestudiedafter12yr.Furtherdetailsconcerningthispopula-tionstudyhavebeenpresentedelse-RESULTS—Afamilyhistoryofdiabetesinmothersbutnotfathersshowed,inwhere(4,8-10).univariateanalysis,asignificantpositiveassociationwithobesityexpressed
6、asBM1.AfamilyhistoryofdiabetesinthemotherswasinverselyrelatedtobodyfatdistributionClinicalexaminationexpressedasWHR.NootherassociationwasobservedbetweenfamilyhistoryofdiabetesIntheinitialstudyin1968-1969andinandWHRTheassociationwithBMIwasindependentofage,WHR,smokinghabits,thest
7、udyin1980-1981,bloodsamplesbloodglucose,systolicbloodpressure,serumcholesterol,serumtriglycerides,maternalweretakenafterovernightfasting(8,10).obesity,andtheincidenceofdiabetesduringthe12-yrfollow-upperiod.TwelveyearsBodyweightwasmeasuredtothenearestlater,in1980-1981,anindepend
8、entassociationstillexistedbetweenfamilyhistoryfor0.1kg