obesity and body fat distribution in relation to the incidence of non-insulin-dependent diabetesmellitus

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1、AmericanJournalofEpidemiologyVol136,No.12mCopyrightO1992byTheJohnsHopkinsUniversitySchoolofHygieneandPublicHealthPrintedinU.S.A.AlrightsreservedObesityandBodyFatDistributioninRelationtotheIncidenceofNon-lnsulin-dependentDiabetesMellitusAProspectiveCohortStudyofMenintheNormativeAgingStudy

2、PatriciaA.Cassano,12BernardRosner,2PantelS.Vokonas,3andScottT.Weiss24DownloadedfromTherelationbetweentheabdominalaccumulationofbodyfat,total-bodyadiposity,andbloodglucoselevelandtheriskofnon-insulin-dependentdiabetesmellituswasevaluatedprospectivelyamong1,972maleparticipantsintheDepartme

3、ntofVeteransAffairsNormativeAgingStudycohort.Theriskofnon-insulin-dependentdiabetesmellituswasassessedbymeansoftheproportionalhazardsmodel;226casesofdiabetesoccurredamongthe1,972men(meanageatentry,41.9years;range,22-80http://aje.oxfordjournals.org/years)over35,496person-yearsofobservatio

4、n.Therelationofbodymassindextodiabetesriskwaspartlyexplainedbybodyfatdistribution;afteradjustingforage,theratioofabdominalcircumferencetohipbreadth,andcigarettesmoking,meninthetoptertileforbodymassindexhada1.3-foldgreaterriskofdiabetesthandidmeninthelowesttertile(95%confidenceinterval0.9

5、-1.8).Moreover,afteradjustingforage,bodymassindex,andcigarettesmoking,meninthetoptertilefortheratioofabdominalcircumferencetohipbreadthhada2.4-foWgreaterriskofdiabetesthandidmeninthelowesttertile(95%confidenceinterval1.7-3.7).WhenbloodglucosewasanalyzedasatUniversityofCalifornia,SanDiego

6、onMay13,2013acontinuousoutcomevariable,thefindingswereconsistent,i.e.,apositiveassociationwithabdominalfatindependentoftotal-bodyadiposity.TheseresultsconfirmpreviousreportsofaprospectiverelationbetweenabdominaladiposityandtheriskofdiabetesandprovideprospectiveevidenceofarelationbetweenW

7、oodglucoselevelsandbothbodyfatdistributionandobesity.AmJEpidemiol1992;136:1474-86.bloodglucose;bodycomposition;diabetesmellitus,non-insulin-dependent;obesityNon-insulin-dependentdiabetesmellitusplayofseveralfactors.Studiesoftwinsand(NIDDM)isanimportantcauseofmorbid-ofhigh