Adipose tissue transplantation may be a potential treatment for diabetes, atherosclerosis and nonalcoholic steatohepatitis

《Adipose tissue transplantation may be a potential treatment for diabetes, atherosclerosis and nonalcoholic steatohepatitis》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、MedicalHypotheses72(2009)247–249ContentslistsavailableatScienceDirectMedicalHypothesesjournalhomepage:www.elsevier.com/locate/mehyAdiposetissuetransplantationmaybeapotentialtreatmentfordiabetes,atherosclerosisandnonalcoholicsteatohepatitisMadhusudanaGirijaSanal*Specia

2、lCenterforMolecularMedicine,JawaharlalNehruUniversity,NewDelhi110067,IndiaDepartmentofGastroenterology,GBPantHospital,NewDelhi110002,IndiaarticleinfosummaryArticlehistory:Adiposetissueiscriticalinenergyhomeostasis.Adiposetissue‘buffers’thelipidsandenergyrichcom-Receiv

3、ed5October2008poundswhicharepumpedintothebloodstreamsoonaftermeals.Itsenses,signalsotherorganslikeliverAccepted13October2008andbrainabouttheenergyreservesviaadipokines.Adiponectin,themostabundantadipokinehasinsu-linsensitizing,anti-inflammatoryantiatherogenicandantiste

4、atoticeffects.Adiposetissuedysfunctionisaccompaniedbyabnormallipiddistributionandstoragewhichcontributestodiseaseslikediabetes,non-alcoholicfattyliverdiseaseandatherosclerosis.Obesityandlipodystrophyareassociatedwithdysfunc-tionaladipocytes.Pre-adipocytesareeasytoisol

5、ateandculture.Apersonalizeddepotspecificliposuctiontoremovetheinactiveadipocytesfollowedbyadipocyterepopulationcouldbeusefulinthetreatmentofthesediseases.Ó2008ElsevierLtd.Allrightsreserved.Toanaïvereaderthetitlemightseemabsurdfordiseaseslikementininsulinsensitivityandd

6、ecreaseinhepaticsteatosis[3].diabetesatherosclerosisandnonalcoholicfattyliverdiseaseButinterestinglysurgicalremovalofexcessfatdoesnotimprove(NAFLD)areclassicallyassociatedwithobesity.Butconsideringinsulinsensitivity.Thisispossiblybecauseasadipocytesarere-theemergingro

7、leofadiposetissueasanendocrineorgancriticalmovedtheprotectionofferedbyadipokinesisdecreasedaswellinenergyhomeostasis,thechangeinrolefromvillaintoherobe-asthebufferingactionprovidedbyadipocytesonthecirculatingcomesacceptable[1–3].energyrichsubstrates[3,12].Thisadipocen

8、tricviewissupportedAdiposetissuetakesupandstorestheexcessenergyrichsub-bypopulationstudiesaswell.MutationsinPPAR-c(peroxisom