5.23 Tendon Tissue Engineering The Potential Application of Stem Cells

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1、5.23TendonTissueEngineering:ThePotentialApplicationofStemCells,BiologicalFactors,andRepairScaffoldstoImproveRotatorCuffTendonTearsSChaudhury,RJMurphy,andAJCarr,UniversityofOxford,Oxford,UK©2011ElsevierB.V.Allrightsreserved.5.23.1Introduction2925.23.2RotatorCuffAnatomy2925.23.3EtiologyofTears2925.23

2、.4ReducedTendonHealing2925.23.5Tissue-EngineeringApproach2935.23.6WhatAreStemCells?2935.23.7StemCellIdentification2945.23.8PotentialUsesinOtherFields2945.23.9ApplicationtoTendon2945.23.10RotatorCuffTendonApplication2955.23.10.1Two-StepStemCellArthroscopicRegeneration2955.23.10.2One-StepStemCellArth

3、roscopicRegeneration2955.23.10.2.1Acromioplasty2955.23.10.2.2Tuberofracture2965.23.10.2.3StemcellconcentrateinjectionSCI2965.23.10.2.4Bursa2965.23.11WhichProcedureforWhichPatients?2975.23.12DeterminingIdealConditions2975.23.13PotentialProblems2985.23.14Conclusions2985.23.15BiologicalAgents2985.23.1

4、6Scaffolds3015.23.16.1ScaffoldProperties3015.23.16.2ScaffoldMaterials3015.23.16.3MechanicalProperties3035.23.16.4AnimalStudies3045.23.16.5HumanClinicalTrials3045.23.16.6Immunogenicity3045.23.16.7ScaffoldLimitations3075.23.16.8SelectingtheRightPatients3075.23.17ConclusionsandtheFuture307References30

5、8Glossaryevaluatebodytissues.MRIisgenerallyusedtoassesstheacromioplastySurgicalremovalofthefrontedgeofthesofttissuesofthebody.acromionprocessofthescapulaasatreatmentforrotatorrotatorcuffAgroupoffourmusclesandtendonscuffpathology.(supraspinatus,infraspinatus,teresminor,andarthroscopic/arthroscopyKey

6、holesurgerytoajoint.subscapularis)attachedbetweentheshoulderbladeandbursaAsmallsynovialfluid-filledsacfoundinthebodythehumerusthatacttostabilizeandrotatethethatsitsbetweenmovingtissueplanestofacilitateglenohumeraljoint.movementandreducefrictionbetweenthelayers.rotatorcuffrepairSurgicalprocedureofre

7、constructingaglenohumeraljointThe‘ballandsocket’jointofthetornrotatorcufftendon,normallybyreattachingthetendonshoulder.Articulationbetweentheglenoidfossaofthetoboneusingsuturesandaboneanchoringtechnique.sca