5.11 Nanoimprint Lithography and Its Application in Tissue Engineering

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1、5.11NanoimprintLithographyandItsApplicationinTissueEngineeringandBiosensingKLi,KMorton,andTVeres,IndustrialMaterialsInstitute,Boucherville,QC,CanadaBCui,WaterlooInstituteforNanotechnology(WIN),Waterloo,ON,Canada©2011ElsevierB.V.Allrightsreserved.5.11.1Introduction1265.11.2

2、BiosensingApplicationsofNIL1275.11.2.1NILNanostructuresusedasSPRDevices1275.11.2.1.1PropagatingSPRandLocalizedSPR1275.11.2.1.2Extraordinaryopticaltransmissionbiosensor1285.11.2.1.3SPR/LSPRbiosensorfabricatedbyusingNIL1295.11.2.1.4SERSbiosensor1295.11.2.2NonplasmonicOptical

3、Biosensors1315.11.2.3ElectricalandElectrochemicalBiosensors1325.11.2.4NILApplicationinNEMS-BasedBiosensor1335.11.2.5FabricationofMicro-NanofluidicsUsingNIL1345.11.2.6Summary1355.11.3ApplicationofNILinTissueEngineering1355.11.3.1Introduction1355.11.3.2DifferentFeatureSizesa

4、ndCuesThatCellReactsto1355.11.3.3ExamplesofApplicationofNILinTissueEngineering1355.11.4Appendix:AdditionalReferences1375.11.4.1AdditionalReferencesforBiosensors1375.11.4.2AdditionalReferencesinSERSandOptofluidicBiosensor1385.11.4.3AdditionalReferencesintheApplicationofNILf

5、ortheFabricationofFETandNanofluidics,andforTissueEngineering138References138RelevantWebsites139Glossaryduplicatedintoamaterialcalledresist.ItoffershighcontactguidanceThephenomenonthatanisotropicresolutionsuperiortothatofelectronbeamlithography,topographicfeaturesinducecell

6、stoalignalongtheandhighthroughputcomparabletothatofdirectionoftheanisotropy.photolithography.extraordinaryopticaltransmissionGreatlyenhancedRamanscatteringInelasticscatteringoflightwiththelatticetransmissionoflightthroughaperiodicsubwavelengthinasolidoramolecule,wheretheph

7、otoneithergainsorholearrayinanotherwiseopaquemetallicfilm,whichislosesenergybyabsorbingorexcitingaphonon.Asaresult,duetolightcouplingbysurfaceplasmonresonance.thefrequencyofthephotonisshiftedafterscattering.nano-electromechanicalsystem(NEMS)surface-enhancedRamanscattering(

8、orspectroscopy)12Miniaturizationintothenanoscaleofso-calledmicro-Enormousenhancement(upto