5.28 Tissue-Engineering Technology for Tissue Repair and Regeneration

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1、5.28Tissue-EngineeringTechnologyforTissueRepairandRegenerationWLiuandYCao,ShanghaiJiaoTongUniversitySchoolofMedicine,Shanghai,China©2011ElsevierB.V.Allrightsreserved.5.28.1Introduction3545.28.2BasicPrinciplesofTissueengineering3555.28.2.1SeedCellSources3555.

2、28.2.1.1Maturedifferentiatedcells3555.28.2.1.2Stemcells3555.28.2.2Scaffoldmaterials3565.28.2.3Tissueformationenvironments3595.28.3TissueGenerationwithTissue-EngineeringTechnology3595.28.4ApplicationofEngineeredTissueforTissueRepair3615.28.4.1BoneTissueEngine

3、eringandRepair3615.28.4.2CartilageTissueEngineeringandRepair3645.28.4.3TendonTissueEngineeringandRepair3675.28.5ClinicalApplicationofEngineeredTissueRepair3715.28.6DevelopmentofEngineeredTissueProducts3715.28.7Summary373Acknowledgments373References373Glossar

4、ycell–matrixinteractionAprocessbywhichmatrixisableadipocyteThemajorcelltypeoffattissue.tosendsignalstothecellsandaffectcellbehaviors.adipose-derivedstemcell(ASC)MSCderivedfromchitosanThedeacylatedderivativeofchitinandaadiposetissue.naturallyoccurringpolysacc

5、haridewhichisusuallyadultstemcellAnundifferentiatedcellthatresidesextractedfromcrustaceanexoskeletonsorgeneratedbyamongdifferentiatedcellsinatissueoranorgan,fungalfermentationprocesses.whichcanrenewitselfandisabletodifferentiateandchondrocyteThemajorcelltype

6、ofcartilagetissue.generatemajorspecializedcelltypesofthetissueorcollagenAgroupofnaturallyoccurringproteinsandtheorgan.mainproteinofconnectivetissue.allogeneicgraftTissuegraftderivedfromdifferentdifferentiatedcellFullymaturecellwithitsparticularindividuals.sh

7、apeandfunctiondistinguishablefromothertypesofautologousgraftTissuegraftderivedfrompatient’sowncells.tissue.embryonicstem(ES)cellDerivedfrominvitro-fertilizedbioceramicsBiocompatibleceramicmaterialswhichareeggswithunlimitedproliferationpotentialandself-usuall

8、ycomposedofinorganicsubstancesuchascalciumrenewalfunctionandabletodevelopintocellsandtissuesphosphateorcalciumbicarbonate.ofthethreeprimarygermlayers.biocompatibilityThepropertyofascaffoldmateri