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1、JournalofNeuroscienceResearch88:3206–3214(2010)CerebralTissueRepairandAtrophyAfterEmbolicStrokeinRat:AMagneticResonanceImagingStudyofErythropoietinTherapy11111GuangliangDing,QuanJiang,LianLi,LiZhang,YingWang,1211ZhengGangZhang,MeiLu,SwayampravaPanda,QingjiangLi,JamesR.Ewing,1andMichaelC
2、hopp1,3*1DepartmentofNeurology,HenryFordHospital,Detroit,Michigan2DepartmentofBiostatisticsandResearchEpidemiology,HenryFordHospital,Detroit,Michigan3DepartmentofPhysics,OaklandUniversity,Rochester,MichiganUsingmagneticresonanceimaging(MRI)protocolsofoftheshorttherapeuticwindowafteronse
3、tofischemiaT2-,T2*-,diffusion-andsusceptibility-weightedimaging(Grottaetal.,2001;Morgensternetal.,2002).Clinical(T2WI,T2*WI,DWI,andSWI,respectively)witha7Ttrialsofneuroprotectivetreatmentsforacutestrokesystem,wetestedthehypothesisthattreatmentofem-patientshavefailed(Adamsetal.,2003,2005
4、;Ovbiagelebolicstrokewitherythropoietin(EPO)initiatedat24hretal.,2003).Thus,cerebraltissuereparativetherapyandadministereddailyfor7daysafterstrokeonsetwarrantsdevelopmentforthetreatmentofischemichasbenefitinrepairingischemiccerebraltissue.Adultstroke.Wistarratsweresubjectedtoembolicstrok
5、ebymeansEndogenousreparativeprocessesofcerebraltissue,ofmiddlecerebralarteryocclusion(MCAO)andwereincludingangiogenesisandneurogenesis,areinitiatedrandomlyassignedtoatreatment(n511)oracontrolafterstrokeonset(Krupinskietal.,1994;Plateetal.,(n511)group.ThetreatedgroupwasgivenEPOintra-1999
6、;CramerandChopp,2000;Zhangetal.,2000;peritoneallyatadoseof5,000IU/kgdailyfor7daysParentetal.,2002;Yuetal.,2007).Focalischemicstarting24hrafterMCAO.Controlsweregivenaninjuryincreasesneurogenesisinthesubventricularzoneequalvolumeofsaline.MRIwasperformedat24hranddirectsneuroblastmigrationt
7、ositesofdamage,andandthenweeklyfor6weeks.MRIandhistologicalneuroblastsarecapableofreplacingsomeneuronslostmeasurementswerecomparedbetweengroups.Serialafterischemicinjury(Zhangetal.,2001,2004;ParentT2WIdemonstratedthatexpansionoftheipsilateraletal.,2002).However,fewnewborncellss
