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1、[FrontiersinBioscienceS1,23-32,January1,2009]Tendontissueengineeringwithmesenchymalstemcellsandbiografts:anoptionforlargetendondefects?1,431,41,2,4XiaoChen,XiaoHuiZou,GuoLiYin,HongWeiOuyang12TissueEngineeringCenter,SchoolofMedicine,ZhejiangUniversity,Hangzhou,P.R
2、..China,DepartmentofOrthopedic3Surgery,SirRawRawShawHospital,SchoolofMedicine,ZhejiangUniversity,Hangzhou,P.R..China,Women'sHospital,4SchoolofMedicine,ZhejiangUniversity,Hangzhou,P.R.China,InstituteofCellBiology,SchoolofMedicine,ZhejiangUniversity,Hangzhou,P.R..C
3、hinaTABLEOFCONTENT1.Abstract2.Introduction3.MSCsasseedcellsfortendonrepair4.MSCsbasedtendontissueengineering5.Decellulargraftsfortendonrepair5.1.Graftsacceptedincurrentclinicalpractice5.2.Currentresearchesonthedecelullartechnologyandimmunogenicityofbiografts6.MSC
4、srevitalizeddecellulargrafts6.1.Currentresearchesontherepopulationoftendongrafts6.2.MSCscellsheetrepopulatedtendonallograft7.Futuredirections8.Acknowledgment9.Reference2.INTRODUCTION1.ABSTRACTItisdifficultfortendontoregenerateafterThemostimportantfactorsinthetiss
5、ueinjury.Thislimitedcapabilityoftendonstoregenerateengineeringapproachtotissuerepairandregenerationareposesachallengetotendontissueengineering,andtheuseofappropriatecellsandscaffolds.Mesenchymalemphasizestheimportanceofdevelopingaproceduretodostemcells(MSCs)areon
6、eofthemostpromisingseedcells,so.whichcanbeeasilyderivedandhavethepotentialtodifferentiateintovariousmesenchymalcelltypesaswellasSofar,fewerstudieshavebeenperformedontenocytesinvitroandinvivo.Biologicaltendongraftsaretendontissueengineeringwhencomparedtotheextensi
7、vethemostcommonchoiceincurrentclinicalpractice,asworkonboneandcartilagetissueengineering.Moreover,theypossessphysicalstructure,strengthandtendontissueengineeringresearchhasnotyetundergonebiocompatibility.Wereviewthelatestresearchfindingsontranslationfromthebencht
8、othebedside.ThecontinuedMSC-basedtendontissueengineeringandrecentadvancesdevelopmentoftendontissueengineeringwilldependoninbiologicalgraftresearch.23Mesenchyma
