Peripheral nerve and skeletal muscle.doc

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1、1325Chapter27-PeripheralNerveandSkeletalMuscleDouglasC.AnthonyMD,PhDMatthewP.FroschMD,PhDUmbertoDeGirolamiMD•Chapter27-PeripheralNerveandSkeletalMuscle•Normal»NORMALPERIPHERALNERVE»NORMALSKELETALMUSCLE•Pathology–GeneralReactionsoftheMotorUnit»SEGMENTALDEMYELINATION»AXONALDEGENERATION

2、ANDMUSCLEFIBERATROPHY»NERVEREGENERATIONANDREINNERVATIONOFMUSCLE»REACTIONSOFTHEMUSCLEFIBER–DiseasesofPeripheralNerve»INFLAMMATORYNEUROPATHIES•Immune-MediatedNeuropathies•Guillain-BarréSyndrome(AcuteInflammatoryDemyelinatingPolyradiculoneuropathy)•Pathogenesis.•Morphology.•ClinicalCour

3、se.•ChronicInflammatoryDemyelinatingPolyradiculoneuropathy»INFECTIOUSPOLYNEUROPATHIES•Leprosy•Diphtheria•Varicella-ZosterVirus»HEREDITARYNEUROPATHIES•HereditaryMotorandSensoryNeuropathyTypeI•MolecularGenetics.•Morphology.•ClinicalCourse.•OtherHereditaryMotorandSensoryNeuropathies»HMS

4、NII•Dejerine-SottasDisease(HMSNIII)»ACQUIREDMETABOLICANDTOXICNEUROPATHIES•PeripheralNeuropathyinAdult-OnsetDiabetesMellitus•Morphology.•ClinicalCourse.•MetabolicandNutritionalPeripheralNeuropathies•NeuropathiesAssociatedwithMalignancy•ToxicNeuropathies»TRAUMATICNEUROPATHIES»TUMORSOFP

5、ERIPHERALNERVE–DiseasesofSkeletalMuscle»DENERVATIONATROPHY•SpinalMuscularAtrophy(InfantileMotorNeuronDisease)•Genetics.•Morphology.•ClinicalCourse.»MUSCULARDYSTROPHIES•X-LinkedMuscularDystrophy(DuchenneMuscularDystrophyandBeckerMuscularDystrophy)•PathogenesisandGenetics.•Morphology.•

6、ClinicalCourse.•AutosomalMuscularDystrophies•MyotonicDystrophy•Pathogenesis.•Morphology.•ClinicalCourse.»IONCHANNELMYOPATHIES(CHANNELOPATHIES)•Pathogenesis.»CONGENITALMYOPATHIES»MYOPATHIESASSOCIATEDWITHINBORNERRORSOFMETABOLISM•LipidMyopathies•Morphology.•MitochondrialMyopathies(Oxida

7、tivePhosphorylationDiseases)•Morphology.•ClinicalCourseandGenetics.»INFLAMMATORYMYOPATHIES•NoninfectiousInflammatoryMyopathies•Dermatomyositis.•Polymyositis.•InclusionBodyMyositis.•EtiologyandPathogenesis.•Morphology.•Dermatomyositis.•Polymyositis.•InclusionBodyMyositis.»TOXICMYOPATH

8、IES•Thyrotox