labelled peptides for imaging of peripheral receptors

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1、IAEA-TECDOC-121499mTclabelledpeptidesforimagingofperipheralreceptorsFinalreportofaco-ordinatedresearchproject1995–1999April2001TheoriginatingSectionofthispublicationintheIAEAwas:IndustrialApplicationsandChemistrySectionInternationalAtomicEnergyAgencyWagram

2、erStrasse5P.O.Box100A-1400Vienna,Austria99mTcLABELLEDPEPTIDESFORIMAGINGOFPERIPHERALRECEPTORSIAEA,VIENNA,2001IAEA-TECDOC-1214ISSN1011–4289©IAEA,2001PrintedbytheIAEAinAustriaApril2001FOREWORD99mTcradiopharmaceuticalshaveremainedtheworkhorseofdiagnosticnuclea

3、rmedicineoverthelastthreedecadeseversincetheintroductionofthegammacameraasthemainimaginginstrument.Duetothenearidealnuclearpropertiessuchasgammaenergy,half-life,lackofbetaradiationandeasyavailabilityasaconvenientgeneratorsystematan99m99maffordablecostofTc,

4、itcanbereasonablyanticipatedthatTcwillcontinuetoretainthispositionintheforeseeablefuture.Toalargeextentthishasbeenpossiblebecauseofthe99msuccessfuldevelopment,overtheyears,ofTcradiopharmaceuticalsassubstitutesforother99mclinicallywellestablishedagents.Exam

5、plesofthesesuccessstoriesareTcsubstitutesfor131201123Ihippuranandrosebengal,TlandIbrainperfusionagents,whichhavecometobe99mknowncollectivelyas‘secondgenerationTcradiopharmaceuticals’.Itshouldbeacknowledgedthateachoneofthesedevelopmentswasaresultofinnovativ

6、eandsustainedresearchanddevelopmenteffortsbyscientistsfromdifferentpartsoftheworld.Concurrentlytheseresearcheffortshavemadesignificantcontributionstobetterunderstandingofthe99mradiochemistryandco-ordinationchemistryofTc.Theradiopharmaceuticalscientistsare9

7、9mnowinamuchbetterpositiontodesign,prepareandevaluateTccomplexesforspecific99mapplications.Buildingonthiscapability,thenextstepisdevelopmentofTcsubstitutesforreceptorspecificradiopharmaceuticals,whichhaveestablishedclinicalpotential.Effortsin99mthisdirecti

8、onarealreadyongoingandtheworkduringthelastdecadeonTclabellingof99mmonoclonalantibodiescanbeconsideredthebeginningofthese‘thirdgenerationTcradiopharmaceuticals’.TheInternationalAtomicEnergyAgency(IAEA)hadorgan