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1、MolecularPharmacologyFastForward.PublishedonMarch14,2006asDOI:10.1124/mol.106.022772MolecularPharmacologyFastForward.PublishedonMarch14,2006asdoi:10.1124/mol.106.022772Thisarticlehasnotbeencopyeditedandformatted.Thefinalversionmaydifferfromthisversion.MOL#22772Determinationofbindingsiter
2、esiduesresponsibleforthesubunitselectivityofnovelmarine-derivedcompoundsonkainatereceptorsDownloadedfromJamesM.Sanders,OlliT.Pentikäinen,LucaSettimo,UllaPentikäinen,MuneoShoji,MakotoSasaki,RyuichiSakai,MarkS.Johnson,andGeoffreyT.Swansonmolpharm.aspetjournals.orgDepartmentofPharmacologyan
3、dToxicology,UniversityofTexasMedicalBranch,301UniversityBlvd.,Galveston,TX.(JMS,GTS)DepartmentofBiochemistryandPharmacy,ÅboAkademiUniversity,Tykistökatu6A,FI-20520Turku,Finland.(OTP,LS,MSJ)DepartmentofPharmacology,UniversityofBristol,BristolBS81TD,UnitedKingdom.(UP)TheSchoolofChemistry,U
4、niversityofBristol,BristolBS81TS,UnitedKingdom.atASPETJournalsonMay24,2018LaboratoryofBiostructuralChemistry,GraduateSchoolofLifeSciences,TohokuUniversity,Aoba-ku,Sendai,Japan.(MuS,MaS)SchoolofFisheriesSciences,KitasatoUniversity,Kesen-gunSanriku-cho,Iwate,022-0101Japan.(RS)1Copyright200
5、6bytheAmericanSocietyforPharmacologyandExperimentalTherapeutics.MolecularPharmacologyFastForward.PublishedonMarch14,2006asDOI:10.1124/mol.106.022772Thisarticlehasnotbeencopyeditedandformatted.Thefinalversionmaydifferfromthisversion.MOL#22772Runningtitle:BindingsiteresiduesresponsibleforK
6、ARselectivityCorrespondenceto:GeoffreyT.SwansonDepartmentofPharmacologyandToxicologyUniversityofTexasMedicalBranch301UniversityBlvd.Galveston,TX77555Tel:(409)772-9653Fax:(409)772-9642Email:g.swanson@utmb.eduDownloadedfromTextpages:43Numberoftables:1Numberoffigures:7Numberofreferences:45m
7、olpharm.aspetjournals.orgWordsinAbstract:249WordsinIntroduction:665WordsinDiscussion:1494AbbreviationsAMPA,(S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid;ATPA,(RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoicacid;DNQX,2-(triethylamino)-N-(2,6-dimethyl
