study on the physiological function and application of γ―aminobutyric acid and its receptors

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1、Studyonthephysiologicalfunctionandapplicationofγ―aminobutyricacidanditsreceptors　　Abstract：γ-aminobutyricacid（GABA）isafunctionalnonproteinaminoacid，whichiswidelydistributedinanimalsandplants，inmanykindsofmetabolicactivities，physiologicalactivityisveryhigh.

2、Intheanimal，asanimportantinhibitoryneurotransmitter，GABAconcentrationinnervetissue，andthecontentinthebraintissueofabout0.1-0.6mg/grams.WiththegradualdeepeningofGABAresearch，GABAhasbeenmoreandmorewidelyusedinfood，animalhusbandryandotherindustries.Thispaperm

3、ainlyanalyzesthephysiologicalfunctionofGABAanditsreceptor，anditsapplicationisalsodiscussedforourreferenc.　　Keywords：γ-aminobutyricacid；γ-aminobutyricacidreceptor；physiologicalfunction　　1Introduction　　γ-aminobutyricacid（GABAB）isknownasaminobutyricacid，which

4、isanimportantinhibitoryneurotransmitter.About50%ofthecentralsynapticsiteisGABAasatransmitter，toregulatethebodyfunction.Thereare3subtypesofGABAreceptor，namely，GABAAreceptor，GABABreceptorandGABACreceptor.GABABreceptorisakind13ofmetabolicreceptor，GABAArecepto

5、randGABACreceptorareionicreceptor，whichplaysakeyroleinthecentralnervoussystemandperipheraltissues，whichcanregulateautism，depression，epilepsyandmentaldisorders，suchasmentaldisorders，andcanalsobeusedasfeedadditivetoalleviatetheharmcausedbythestressresponseto

6、animalhusbandry.Therefore，itisveryimportanttostudyGABAanditsreceptors.　　2PhysiologicalcharacteristicsofGABAanditsreceptors　　2.1PhysiologicalcharacteristicsofGABA　　GABAsubtypeisC4H9NO2，Subsubqualityof103.12u，whichiswidelydistributedinanimals，plantsandmicroo

7、rganisms，thehighestconcentrationofmammalianbraintissue，mainlydistributedinthethalamus，hippocampus，basalgangliaandotherregions.Itcanreducethecellmetabolismandtheactivityofneurons，reducetheinfluxofions，andcanpromotetheactivityoftheparasympatheticnervoussyste

8、m，suchascompression，antiinsomniaandotherbeneficialeffects.GABAandL-glutamicacid（Lglutamicacidcontentinthecentralnervoussystemareinhighlevel，L-glutamicacidmaintransfernerveimpulses，andGABaasaninhibitoryneurotr