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1、Virology290,173–180(2001)doi:10.1006/viro.2001.1160,availableonlineathttp://www.idealibrary.comonMINIREVIEWReovirusReceptorsandApoptosis,,1,,2,,3,,,,4ErikS.Barton,*†JamesD.Chappell,†‡JodiL.Connolly,*†J.CraigForrest,*†andTerenceS.Dermody*†‡*DepartmentofMicrobiologyandI
2、mmunology,‡DepartmentofPediatrics,and†ElizabethB.LambCenterforPediatricResearch,VanderbiltUniversitySchoolofMedicine,Nashville,Tennessee37232ReceivedJuly23,2001;acceptedAugust1,2001INTRODUCTIONconsiderableefforthasbeenfocusedonstudiesof1structure,1receptors,andmecha
3、nismsbywhich1–Themammalianreovirusesareatractableexperimen-receptorinteractionsleadtocellularinjury.talsystemforstudiesofviralreplicationandpathogen-esis.Reovirusvirionsarenonenveloped,double-shelled1ISAFIBROUSPROTEINWITHparticlescontainingagenomeof10segmentsofdoubl
4、e-HEAD-AND-TAILMORPHOLOGYstrandedRNA(NibertandSchiff,2001).Reoviruseshavebeenisolatedfrommanymammalianspecies,includingAnalysisofstructure–functionrelationshipsofreo-humans,butreovirusdiseaseislimitedtotheveryyoungvirusattachmentprotein1hasfocusedprimarilyon(Tyler,20
5、01).Thepathogenesisofreovirusinfectionhastype31,withneurovirulentstraintype3Dearingbeenstudiedusingnewbornmice,inwhichserotype-(T3D)servingasaprototype.Type11hasbeenlessspecificpatternsofdiseasehavebeenidentified(Tyler,wellstudied,andpublishedreportshavebeenlimited2
6、001).Thebestcharacterizedofthesemodelsisreovirustostraintype1Lang(T1L).Currentunderstandingofpathogenesisinthemurinecentralnervoussystem1biologyisderivedfromstudiesofvirion-associated(CNS)(Fig.1).Afterprimaryreplicationintheintestine,1aswellas1proteinisolatedfromvi
7、rionsortype1reovirusstrainsspreadbyhematogenousroutesproducedusingprokaryoticoreukaryoticexpressiontotheCNSwheretheyinfectependymalcells,leadingtosystems.Thisbodyofresearchhasculminatedinanonlethalhydrocephalus(Weineretal.,1977,1980;Tylermodelof1structureinwhichseque
8、ncesinvolvedinetal.,1986).Incontrast,type3reovirusesspreadprimar-receptorbindingarecorrelatedwithdistinctmorpho-ilybyneuralr
