MicroRNAs in Cardiac Apoptosis

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1、J.ofCardiovasc.Trans.Res.(2010)3:219–224DOI10.1007/s12265-010-9175-9MicroRNAsinCardiacApoptosisPeifengLiReceived:26November2009/Accepted:17February2010/Publishedonline:19March2010#SpringerScience+BusinessMedia,LLC2010AbstractMicroRNAs(miRNAs)aresmallandhig

2、hlyspecificmiRNA,miR-1-2,revealsnumerousfunctionsinconservednon-codingRNAmoleculesthatfunctiontotheheartincludingregulationofcardiacmorphogenesis,regulategeneexpression.Theyplayimportantrolesinelectricalconduction,andcell-cyclecontrol[3].Theseregulatingcar

3、diacphysiologicalandpathologicaleventsresultssuggestthatmiRNAsplaycriticalrolesinmaintain-suchashypertrophy,apoptosis,andheartfailure.Induc-ingnormalcardiacstructureandfunction.Cardiomyocytetionofapoptosisincardiomyocytescannotbecompen-apoptosisisrelatedto

4、cardiacdisorderssuchasmyocardialsatedbyefficientcellproliferation,therebyleadingtoinfarction,cardiomyopathy,cardiachypertrophy,andpathophysiologicaldisorders.ThemiRNAsinvolvedinanthracycline-inducedcardiotoxicity[4–10].Thegrowingcardiacapoptosismayprovidea

5、mechanismfortheevidencedemonstratesthatmiRNAscanregulateapoptosispathogenesisandtreatmentofheartdiseases.Thisreview[11–14].ThisarticlereviewstheroleofmiRNAsinsummarizestheroleofmiRNAsinregulatingcardiacregulatingcardiacapoptosis.Specifically,itdiscussesthe

6、apoptosis.Inparticular,itdiscussesthepotentialthera-potentialtherapeuticapproachesforapoptosis-relatedcar-peuticapproachesforapoptosis-relatedcardiacdiseasesbydiacdiseasesbymodulatingmiRNAs.modulatingmiRNAs.KeywordsApoptosis.miRNA.HeartHowdomiRNAsRegulateA

7、poptosis?ApoptosiscanbeinitiatedbyavarietyofmiRNAs.miR-Introduction200aisabletotargettheE-cadherinandWnt/β-cateninsignalingpathways[15].E2F1isnegativelyregulatedbyMicroRNAs(miRNAs)areaclassofsmallnon-codingmiR-330,thelatterinducesapoptosisthroughE2F1-RNAst

8、hatmediateposttranscriptionalgenesilencing.mediatedsuppressionofAktphosphorylation[16].miR-Recently,theworkonmiRNAsrenovatesourunderstand-122modulatescyclinG1silencingandincreasessensitivityingaboutthegenereg