《药物效应动力学》PPT课件

《《药物效应动力学》PPT课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、Chapter3PharmacodynamicsContentsContents1、Basicaction2、Therapeuticeffect3、Adversereaction4、Dose-effectrelationship5、Mechanismofaction1、BasicactionandPharmacologicaleffectDrugactionPrimaryactiondrugactingbodyeffectsecondactionTwoeffectExcitation：Inhibition：

2、（兴奋）（抑制）正常正常强壮烦躁不安惊厥死亡Excitation镇静催眠麻醉回苏麻痹死亡Inhibitiontwocharacteristics:1)specificity（特异性）drug2)Selectivity（选择性）(tissuebinding)2.Therapeuticeffectthetherapeuticgoal.Favorabletothenormalizationofphysiological,biochemicalfunctions.治疗目标therapeuticeffects1、Et

3、iologicaltreatment2、Symptomatictreatment急則治标，缓则治本标本兼治，不可偏废也治疗效果1)EtiologicaltreatmentAimstoeliminatepathogenicfactore.g.antibiotics-----microbesinfection2)SymptomatictreatmentAimstoallayoramelioratesymptome.g.analgesics---analgesia对因治疗对症治疗isadoubleedgedswo

4、rd!Drug3.AdversereactionSidereaction（副作用）Accompaniedbythetherapeuticeffect.AppearsatthetherapeuticdoseDependsdrug`sintrinsicaction.Expectable.CanbemoderatedToxicreaction（毒性反应）ResultsfromoverdoseandexcessiveaccumulationofdrugCanbeexpectableShouldbeprevented

5、1）circulationAcuteToxicreaction2）respiratory3）nervous1）liver,kidney3）endocrine2）bonemarrowchronicToxicreaction4）other⑴Carcinogenesis（致癌）chronic4）other⑵Teratogenesis（致畸）⑶Mutagenesis（致突变）血药浓度降至有效浓度以下时残存的效应。Residualeffect（后遗效应）Withdrawalreaction（停药反应）reboundr

6、eaction（回跃反应）：突然停药后原有疾病加剧。Allergicreaction(变态反应)hypersensitivereaction1）unconcernedwithdose2）varyfromdrugtodrugandpersontoperson(因药而异，因人而异)（过敏反应）(与剂量无关)Idiosyncrasy（特异质反应）先天遗传异常某些药物高敏。glucose-6-phosphatedehydrogenase(葡萄糖-6-磷酸脱氢酶)geneticenzymedefects(遗传的缺陷)

7、,Concentration-effectrelationship（浓效关系）Dose-responsecurve(量效曲线)Gradeddose-responsecurve(量反应曲线)Dose-effectrelationship（量效关系）量效关系1.dose/dosage（剂量）用药的分量2、Dose-effectrelationship在一定的范围内药理效应与剂量成正比。3、dose-effectcurve，D-E曲线（量-效曲线）。100%50%E（A）C长尾S型曲线（B）LogC对称S型曲线E

8、maxEmaxFig3-1药物作用的量效关系曲线E100%50%0.1110300pD2C亲和力指数pD2与亲和力成正比作用强度最小有效量常用量（治疗量）极量最小中毒量最小致死量剂量量效曲线Response(%)concentration10987ECminEmin100%50%EminECmaxEmaxEC50Efficacy(效能)maximaleffect（最大效应）.Relativeconcentrati