特发性膜性肾病和iga肾病患者血清脂肪型脂肪酸结合蛋白的检测和意义

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1、授予单位代码10089学号或申请号11196HebeiMedicalUniversity硕士学位论文在职科学学位特发性膜性肾病和IgA肾病患者血清脂肪型脂肪酸结合蛋白的检测和意义学位申请人：高剑导师：张连珊教授专业：病理学与病理生理学二级学院：基础医学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成《>本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验

2、材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则,承担相应法律责任。研究生签名：导师签章：级学院领导盖章:_1P(V年对月，日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：导师签章：年“月-日目录中文摘要·········································································

3、····1英文摘要·············································································5英文缩写·············································································9研究论文特发性膜性肾病和IgA肾病患者血清脂肪型脂肪酸结合蛋白的检测和意义前言····································································

4、·········10材料与方法····································································11结果·············································································17附图·············································································20附表··························

5、···················································25讨论·············································································27结论·············································································30参考文献·························································

6、··············30综述脂肪型脂肪酸结合蛋白的临床表达···································33致谢···················································································40个人简历·············································································41中文摘要特发性膜性肾病和IgA肾病患者血清脂肪型脂肪酸结合蛋白的检测和意

7、义摘要目的：慢性肾脏病（chronickidneydisease，CKD）已成为目前全世界范围的严重影响人类健康的疾病之一，随着肾穿刺活检的应用和人们对其知晓率的提高,作为肾脏病诊断的金标准，肾脏病病理学分类在CKD指导治疗，判断预后方面起着越来越重要的作用。在原发性肾脏病的病理类型中，IgA肾病（IgAnephropathy,IgAN）是我国乃至东南亚地区发病率最高的病理类型,其共性以IgA和补体C3为主沉积于肾小球系膜区为主要病理诊断依据，由于病理变化多种多样使得临床表现多样；特发性膜性肾病（idiopathicmembranousnephr

8、opathy,IMN）以肾小球基底膜上皮细胞下免疫复合物的沉积伴基底膜弥漫性增厚为主要病理特征，临床表现主要为不同程度的蛋白尿及肾病综合