glp-1对氧化激诱导内皮细胞损伤的影响

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1、授予单位代码10089学号或申请号12079HebeiMedicalUniversity硕士学位论文在职科学学位GLP-1对氧化激诱导内皮细胞损伤的影响学位申请人：康岩导师：周慧敏教授专业：内科学二级学院：第一医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学

2、，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则,承担相应法律责任。I.L研究生签名：丨為导师签章^二级学院领导盖章：河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：0导师签章年月曰目录中文摘要····················································

3、··················································1英文摘要······································································································3英文缩写··························································································

4、············6研究论文GLP-1对氧化应激诱导内皮细胞损伤的影响前言······································································································7材料与方法··························································································8结果···········

5、···························································································11附图······································································································13讨论···················································

6、···················································15结论······································································································18参考文献·························································································

7、·····18综述氧化应激与心血管疾病····································································22致谢··············································································································32个人简历·············································

8、·························································33中文摘要GLP-1对氧化应激诱导内皮细胞损伤的影响摘要目的：糖尿病(diabetesmellitus,DM)以长期慢性高血糖为发病基础，胰岛素分泌缺陷和(或)胰岛素抵抗为特征的一组代谢性疾病。随着经济的发展，人们生活方式的改变，糖尿病患病率显著增加。多种代谢紊乱会导致糖尿病血管内皮细胞功能障碍，从而引起一系列的糖尿病血管并发症，据统计糖尿病血管并发症已