通心络改善缺氧性脑损伤的作用机制

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1、授予单位代码10089学号或申请号20122604HebeiMedicalUniversity硕士学位论文科学学位通心络改善缺氧性脑损伤的作用机制研究生：张宇导师：温进坤教授专业：生物化学与分子生物学二级学院：基础医学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研宄所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学

2、，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法侓责任。，UI一，I研宄生签名宇导师签章：丨fL级学院领导盖章:U\JX，I>/!年3月$曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研宄成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名字导师签章:JZP/JT年3月二？目录中文摘要···························

3、·················································································1英文摘要············································································································4英文缩写························································

4、····················································7研究论文通心络改善缺氧性脑损伤的作用机制前言············································································································8材料与方法··································································

5、······························9结果··········································································································14附图··········································································································17讨论··

6、········································································································22结论··········································································································25参考文献···································

7、·······························································25综述血管内皮生物学功能研究新进展······················································28致谢··················································································································37

8、个人简历··········································································································38中文摘要通心络改善缺氧性脑损伤的作用机制摘要目的：通心络对缺血缺氧性脑损伤具有保护作用，但其作用机制目前尚不清楚。本研究在动物模型和细胞水平上研究通心络对脑组织微血管缺氧性损伤的保护作用及其作用机制，为通心