formulation and evaluation of - rguhs：制定和评价- rguhs

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1、DESIGN,OPTIMIZATIONANDEVALUATIONOFORALIN-SITUGELFORANTIINFECTIVEDRUGSYNOPSISFORM.PHARMDISSERTATIONSUBMITTEDTORAJIVGANDHIUNIVERSITYOFHEALTHSCIENCESKARNATAKABYM.PRATHYUSHAIM.PHARMUNDERTHEGUIDENCEOFDR.B.PRAKASHRAOPROFESSOR,HEADOFTHEDEPARTMENTDEPARTMENTOFPHARMACEUTICALTECHNOLOG

2、YKARNATAKACOLLEGEOFPHARMACYBENGALURU-560064(2011-2012)8RAJIVGANDHIUNIVERSITYOFHEALTHSCIENCESKARNATAKA,BANGALORE.ANNEXUREIIPROFORMAFORREGISTRATIONOFSUBJECTFORDISSERTATION1NameoftheCandidateandAddressM.PRATHYUSHAKarnatakaCollegeofPharmacy#33/2,ThirumenahalliHegdeNagarMainRoad

3、Bengaluru-560064.PERMANENTADDRESSD/OM.PRABHAKARREDDYH.NO:7-319,BehindAgroForumRamaChandraGudemMiryalaguda-508207           Nalgonda(Dist)Andhrapradesh.2NameoftheInstitutionKARNATAKACOLLEGEOFPHARMACY#33/2,ThirumenahalliHegdeNagarMainRoadBengaluru-560064.3CourseoftheStudyandS

4、ubjectMASTEROFPHARMACY(PHARMACEUTICALTECHNOLOGY)4DateofAdmission13thJUNE-20115TITLEOFTHEPROJECT:-DESIGN,OPTIMIZATIONANDEVALUATIONOFORALINSITUGELFORANTIINFECTIVEDRUG866.1BRIEFRESUMEOFINTENDEDWORK:-NEEDFORTHESTUDY:-Oraladministrationofdrugshasthemostcommonandpreferredroutefor

5、deliveryofthemostofthedrugs.Inrecentyearsoralcontrolleddelivery(CR)systemshavegainedincreasedimportanceandinterestsinceitisnecessarytoimprovethesystemicabsorptionofthedrugsandpatientcompliance.Inaddition,CRsystemsmaintainuniformdruglevels,reducedose,sideeffectsandincreaseth

6、esafety.Theoralin-situgelformingpolymericdrugdeliverysystemsaredesignedwithanobjectivetoretaininstomachforanextendedtimeperiodandalsoforachievingsystemicdrugeffectsoverthanotherpharmaceuticaldosageforms.In-situgelformingpolymericdrugdeliverysystemshaveshownsomeadvantagessuc

7、haseasyofadministration,reducedfrequencyofadministration,improvedpatientcomplianceandcomfortandIn-situgelsarepreparedtoovercometherapidlyincreasingcostandtoreducethetimerequiredinthedevelopmentworksoverthantheotherpharmaceuticaldosageforms.Thecurrentresearchworkofformulatin

8、goralin-situgelbyusinganti-infectivedrughavingshorterhalflife.Gastrointestinalabso