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1、FORMULATIONANDEVALUATIONOFNANOPARTICLESCONTAININGANANTICANCERDRUGSYNOPSISFORM.PHARM.DISSERTATIONSUBMITTEDTORAJIVGANDHIUNIVERSITYOFHEALTHSCIENCES,KARNATAKABYPRADEEP.DIM.PHARM.DEPARTMENTOFPHARMACEUTICSDAYANANDASAGARCOLLEGEOFPHARMACY2012RAJIVGANDHIUNIVERSITYOFHEALTHSCIENC
2、ESBANGALORE,KARNATAKAANNEXURE-IIPROFAMAFORREGISTRATIONOFSUBJECTSFORDISSERTATION1.Nameofthecandidateandaddress(inblockletters)PRADEEP.DIM.PHARM.,DEPARTMENTOFPHARMACEUTICS,DAYANANDASAGARCOLLEGEOFPHARMACY,KUMARASWAMYLAYOUT,BANGALORE-560078.PERMANENTADDRESS#30,WARDNO:09,AR
3、ALEPETE,RAMANAGARATALUKANDDISTRICT-5621592.NameoftheinstituteDayanandaSagarCollegeofPharmacy,ShavigeMalleswaraHills,KumaraswamyLayout,Bangalore-560078,Karnataka.3.CourseofstudyandsubjectMasterofPharmacyinPharmaceutics4.Dateofadmissiontocourse14AUG20125.Titleoftheprojec
4、t:“FORMULATIONANDEVALUATIONOFNANOPARTICLESCONTAININGANTICANCERDRUG”6.Briefresumeoftheintendedwork:6.1Needofthestudy:Cancerisoneofthemajorcausesofdeathinmanyindustrializedcountriesanditsincidenceiseverincreasing.Deathsfromcancerworldwideareprojectedtocontinuerising,with
5、anestimated12milliondeathsin2030.Therefore,tremendousresourcesarebeinginvestedinprevention,diagnosisandtreatmentofcancer.Discoveryanddevelopmentofanticanceragentsarethekeyfocusofseveralpharmaceuticalcompaniesaswellasnonprofitgovernmentandnongovernmentorganizations1.Tre
6、atmentofcancerincludeschemotherapy,radiationtherapy,genetherapy,photodynamictherapy,biologictherapy,surgicalremovaloftumorcells,etc.,ofthesemethodschemotherapyisthemosteffective,convenientandnon-expensivetreatmentfortumor.Thechallengesofanticancertreatmentbychemotherap
7、euticagentsincludenonselectivedeliveryofcytotoxicdrugstotumorsitesthatleadtoseveresideeffectsduetotheireffectsonnormalnontargetedorgansandtissues2.Inrecentyears,numerousnano-sizeddrugcarriers,suchasmicelles,nanoparticles,polymer–drugconjugates,andstealthliposomes,haveb
8、eeninvestigatedinordertominimizesideeffectsofanticancerdrugsandenhancetheantitumoraldrugefficacyincancertherapy.Acrit
