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1、“FORMULATIONANDINVITROEVALUATIONOFSUSTAINEDRELEASEMATRIXTABLETSOFANANTI-DIABETICDRUG”SYNOPSISFORM.PHARMDISSERTATIONSUBMITTEDTORAJIVGANDHIUNIVERSITYOFHEALTHSCIENCESKARNATAKABYSUSHMITAKUSHWAHA1STMPHARMUNDERTHEGUIDANCEOFDR.SATISHC.SDEPARTMENTOFPHARMACEUTICSPESCOLLEGEOFPHARMACYBANGALORE(2010-11)2R
2、AJIVGANDHIUNIVERSITYOFHEALTHSCIENCES,KARNATAKA,BANGALORE.ANNEXURE-IIPROFORMAFORREGISTRATIONOFSUBJECTSFORDISSERTATION1NameofthecandidateandaddressSUSHMITAKUSHWAHA,D/o.SMT.MANJULAKUSHWAHA,PermanentAddress:FlatNo.SF02,3RDFloor,SVSMansion,1stMain,5thCross,Itammaduext,BSK3rdStage,Bangalore-5600852N
3、ameoftheinstitutionP.E.S.COLLEGEOFPHARMACY50FeetRoad,HanumanthaNagar,Bangalore-560050.3CourseofstudyandsubjectMASTEROFPHARMACYINPHARMACEUTICS4Dateoftheadmission11thOCTOBER20105Titleofthetopic:“FORMULATIONANDINVITROEVALUATIONOFSUSTAINEDRELEASEMATRIXTABLETSOFANANTI-DIABETICDRUG”26.Briefresumeoft
4、heintendedwork:6.1Needforthestudy:Thepopulationofpatientswithchronicdiseaseorcomplicationsofotherdiseasesisrecentlyincreasing.Thesesituationsnecessitatehavingdrugsforalongperiodandtakingalotofmedicinessimultaneously,whichcanleadtoincreaseinnon-complianceofthedrugs.Thisproblemtendstobeseriousfo
5、rdrugswithshortbiologicalhalf-livesbecausetheymustbetakenmorefrequently.Onemethodtosolvesuchproblemsistofindadosageformcapableofreleasingthedruggradually.Variouspolymershavebeenutilizedforthedevelopmentofslowdrugreleasedosageforms.Swellablepolymers,hydrophobicpolymers,etc.areusedfrequentlyasma
6、terialsofmatricesorcoatingmembranesofslowreleasedosageforms.Glipizideisasecondgenerationsulfonylureacommonlyusedasanantidiabeticdruginthetreatmentoftype-IIdiabetesmellitus.Thedosevariesfrom5mgto40mgdailyindivideddoseforimmediatereleasetabletswhileforsustainedreleasetabletsitis10mgtwicedaily.Gl
7、ipizideistobeadministeredfrequently,whichproducedosedependentsideeffectsandpatientnon-compliance,hencesustainedreleasedosageformsarepreferredforthisdrug.Sustainedreleaseformulationsarebetteroverconventionaldeliverysystems,particularlyfo
