中链三酰甘油对脑力疲劳大鼠抗氧化和认知能力的影响

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1、第二军医大学硕士学位论文ABSTRACTBackgroundHumanactivitiesCanbedividedintophysicalandmentallabor．Theyarecompletedintheharmonizationofthecentralnervoussystem(thebrainandspinalcord)．Inmodemsociety,mostofthephysicallaborintensityhasbeenreduced，butthementalstrengthissign

2、ificantlyincreased．Coupledwiththeincreasingpressureonthepaceoflifeandsocialcompetition，expandingcrowdareleadingtomentalfatigueeventually．Thedegreeofmentalfatigueisincreasingtoo．Therefore，mentalfatigueandchronicfatiguesyndromehasbeenaseriousthreattothephy

3、sicalandmentalhealthofthegeneralpopulation．Meanwhile，underthenewsituation，theArmedPoliceForceincreasesthetrainingmissionandtheintensity．Exercise-inducedfatigueandmentalfatiguecausedbymilitarytrainingoccursfrequentlyatthegrass—rootsunits．Therefore，studyin

4、gthemechanismsofmentalfatigueanditspreventionstrategyhasimportantpracticalsignificance．Atpresent，thestudymainlyfoucusesonthenaturalfloraandfauna,naturalextractsofanimalandplant,aminoacids，vitamins，coenzymeQ，caffeine，andSOon．Justafewreportsprovethatmedium

5、-chainfattyacidsCanimproveexercisecapacity．Themediumchainfattyacids(MCFA)isconstitutedby6to12carbonatoms．Itmainlyexistsinpalmoil，coconutoil，nlilkandmilkproducts，mainlyincludeoctanoicacid(CsHl602)anddecanoicacid(CIoH2002)．MCFAexistsinfoodastheformoftdglyc

6、erides，i．e．，themedittm-chaintriglycerides(MCT)．Themedium—chaintriglyceridehasaspecialwayofdigestion，absorptionandutilization．ItCanbequicklyabsorbedandusedtoprovideenergyimmediately。Fromtheliteratureweknowthat，MCTcallreduceserumtriglyceridesandlow-density

7、lipoprotein,improveinsulinresistance，reducetheaccumulationofbodyfat，preventobesity，improveimmunefunctionandpreventbacterialinfections．Thisexperimentbasedonanimalexperimentalmethod，addMCTtoratchow,deprivethesleepofratstocausementalfatiguemodel．Observethee

8、ffectsofmediumchaintriglycerideonrats’serumlipid，antioxidantcapacityandcognitiveability．Postulatethemechanism，andprovidetheexperimentalbasisandtheoreticalsupportfortheroleofmedium—chaintriglyceridesinmentalfatigue．objectiv