局部晚期喉癌和下咽癌调强放疗与二维放疗与三维适形放疗比较的剂量学分析

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1、局部晚期喉癌和下咽癌调强放疗与二维放疗及三维适形放疗比较的剂量学研究dosedistributionontargetvolumeandnormaltissueandorgansforpatientswithlocallyadvancedlaryngealorhypopharyngealcarcinoma．Toevaluatetheadvantagesofintensity-modulatedradiotherapyplans，andtoprovideatheoreticalbasisforthefurtherclinic

2、alresearchandapplication．Materialsandmethods：FromtheparticipateoftheEGF102988studyinthecRncercenter，eightcasesofpostoperativepatients、)vithlocallyadvancedlaryngealorhypopharyngealeareinoma(T3．4Nl一2M0)werechosenfordosimetricanalysis，ofwhich4werelaryngealand4werehy

3、popharyngeal．2D·RT，3D-CRTandIMRTplanweremadeforeachpatientonthesameplantargetvolume．Thedosepresedhedtohigh-riskplantargetvolume@TV1)was66Gy,whichtolow-riskplantargetvolume(PTV2)Was50Gy．TheevaluateindicatorofPTVcontainedthevolumepercentageofwhichcoverdby93％，95％and

4、107％respectively(V95，V93，V107)，．inhomogeneitycoefficient(IC)andconformityindex(CO．Theevaluateindicatorofparotidglandweremeandose(Dmean),thevolumepercentageofreceivingmorethan15Gy,30Gyand45Gyrespeetively(V15Gy,V30Gy,V45Gy)andnormaltissuecomplicationprobability(NTC

5、P)．Theevaluateindicatorofothernormaltissueswerethedosesdeliveredtolem’，5％and33％ofplanningorganatriskvolumerespectively(Dlee，D5，D33)．Tocomparedtheindicatorsaboveforthethreedifferentradiotherapytechniques．Results：ForIMRTgroup、3D-CI玎groupand2D—RTgroupofPTV1，themeanV

6、95were99．20％，96．90％and88．59％，themeanICwere0．123，0．2and0．463，themeanC1were0．858，0．574and0．446，respectively．OfPTV2，themeanV95were98．81％，96．53％and88．21％respectivelyandthemeanC1were0．630，0．568and0．537respectively．Thereweresignificantdifferencesamongthreegroupsontheab

7、oveindicators(P<0．001)．ForPTVl，themeanV93forthreegroupswere99．63％，98．38％and92．56％(P<0．001)，comparedwith3D-CRTand2D—I玎，theIow-doseV局部晚期喉癌和下咽癌调强放疗与二维放疗及三维适形放疗比较的剂量学研究targetvolume(娟1．38Gy)ofIMRTdecreasedby1．3％and7．1％．ForPTV2，themeanV93forthreegroupswere98．99％，97．72％

8、，and90．61％(P<0．001)，compared、^，ith3D-CRTand2D-RT,thelow-dosetargetvolume(<46．5Gy)ofIMRTincreasedby1．3％and8．4％respectively．ForPTVl，themeanV107forthreegroupswere