川芎嗪改善tia患者脑血流速度和微栓子数目的临床观察

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1、提要目的：观察川芎嗪对短暂性脑缺血发作患者脑血流速度和微栓子数目的影响。期望通过观察，为川芎嗪治疗短暂性脑缺血发作提供临床依据。方法：按照入选标准，随机抽取短暂性脑缺血发作患者60名，随机分为基础治疗组（30例）和川芎嗪组（30例），治疗前分别行经颅多普勒超声（TCD）和微栓子监测检查。基础治疗组予阿司匹林肠溶片（拜阿司匹灵）100mgPoQd、氯吡格雷（波立维）75mgPoQd、阿托伐他汀钙片（立普妥）20mgPoQn、盐酸氟桂利嗪胶囊（西比灵）5mgPoQn，川芎嗪组在基础治疗组的基础上加用注射用盐酸川芎嗪(川青)0.24g入生理盐水250

2、mlivdripQd治疗。4周后再行经颅多普勒超声（TCD）和微栓子监测检查，并运用SPASS17.0统计分析软件观察脑血流速度和微栓子数目的改变。结果：统计分析结果显示，治疗前川芎嗪组和基础治疗组脑血流速度和微栓子数目无明显差异(P>0.05)，治疗后两组脑血流速度和微栓子数目比较差异明显（P<0.05)。结论：静脉滴注川芎嗪对改善短暂性脑缺血发作患者的脑血流速度和微栓子数目有显著疗效。关键词短暂性脑缺血发作；川芎嗪；经颅多普勒超声；微栓子监测TetramethylpyrazineImproveinPatientswithTIACerebra

3、lBloodFlowVelocityandMicroemboliNumberofClinicalObservationSpeciality:InternalmedicineofTraditionalChineseMedicineAuther:ZhangyongshengTutor:Pro.YoukeAbstractObjective:ToobservetheeffectsofLigustrazineonpatientswithtransientischemicattackofcerebralbloodflowvelocityandmicroem

4、bolinumbereffect.Hopethatthroughobservation,ligustrazineintreatingtransientcerebralischemicattacktoprovideclinicalbasis.Method:accordingtothecriteria,arandomsampleofpatientswithtransientischemicattackof60,wererandomlydividedintotreatmentgroup(30cases)andligustrazinegroup(30c

5、ases),beforetreatmentweretranscranialDoppler(TCD)andmicroembolimonitoringinspection.Thebasisofthetreatmentgroup(toaspirinBayaspirin)100mgPoQd,clopidogrel(Plavix)75mgPoQd,atorvastatin(Lipitor)20mgPoQncalcium,FlunarizineHydrochlorideCapsules(sibelium)5mgPoQn,ligustrazinegroupi

6、nfoundationtreatmentgroupbasedontheuseofinjectionligustrazinehydrochloride(Chuan)0.24g250mlivdripQdtreatmentinsaline.4weeksaftertranscranialDoppler(TCD)andmicroembolimonitoringinspection,andusingSPASS17.0statisticalanalysissoftwareoncerebralbloodflowvelocityandmicroembolinum

7、berchange.Results:statisticalanalysisoftheresultsshows,beforetreatmentandfoundationofLigustrazinegrouptreatmentgroupflowvelocityandcerebralmicroembolinumbernodifference(P>0.05),aftertreatment,twogroupsofcerebralbloodflowvelocityandmicroembolinumberobviouslydifferent(P<0.05).

8、Conclusions:intravenousinfusionofLigustrazineonimprovementoftransientischem