血清抵抗素与冠状动脉病变的相关性分析

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1、天津医科大学硕士学位论文摘要AbstractBackground：Inthebeginningofthiscentury，theAmericanHeartAcademy(AHA)andAmericanDiabetesAcademy(ADA)hadrealizedthedangerofdiabetesmellitustowardscardiovascularsystem．As60to80percentageofT2DMsuffererdiedofcardiovasculardiseases．AHAandADAadvocatejoininghand

2、stodealwiththatdisease．Aboutfouryearsbefore，theproject，namedNCEPATPIII，wasdrawedoffwhichdiabeteswasasdangerascoronaryheartdisease．Thecomplicationsofdiabeteshavealwaysbeenhighlightedbyclinicdoctors，andreducingthecardiovascularcomplicationbecometheresearchfocuscurently．Inthere

3、centyears，alotofclinicandexperimentalresearcheshaveshownthatatherosclerosisisachronicinflammation．Insulinresistanceaccompanieswiththeincreaseofmanyinflammatoryidentificationsandpromotinginflammatorycellfactors，suchasC—responseproteinandvascularcelladhesionmolecule(VCAM一1)．Th

4、eseinflammatoryfactorsarealsopresentinatherosclerosis．sotheyarethevinculumbetweeninsulinresistanceandatherosclerosis．Resistin，asanewsecretoryproductofadipocytes，becomeanewresearchsubject．Westudiedthecorrelationofresistinandatherosclerosis．Wewanttoknowwhethertheresistinisanid

5、entificationofthecardiovasculardiseaseandwhetheritcouldpredicttheaggravationofdiabetes，obesity，atherosclerosisandcardiovasculardisease．．3．天津医科大学硕士学位论文摘要Objective：Toexploretheassociationbetweenthelevelofresistininserumandtheseverityofcoronaryarteryatherosclerosisthroughcorona

6、ryangiography．Methods：WerandomlycollectsomehospitalizedpatientswithdubiousCHDintheTEDAInternationalcardiovascularhospitalfromSeptembertoDecember，2005．Allthepatientswereperformedcoronaryangiography(CAG)bythetransfemoralapproachoftheJudkinstechnique．Weexaminedthefastingserumre

7、sistinbyELISA．Theconcentrationoffastinginsulinwasassayedbychromogenicmethod，whiletheglucoseconcentrationwasmeasuredbyglucoseoxidasetest．StatisticalanalyseswereperformedwithSPSS12．0．Results：1．ThelevelofresistininserumoftheASgroupissignificantlyhigherthanthecontrol’s．Thepatien

8、tsofdiabetesmellitus，hypertension，smokeroftheASgrouparedividelyhigherthanth