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时间:2020-04-20
《血清糖化白蛋白和同型半胱氨酸与冠状动脉病变的相关性.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·886·中华实用诊断与治疗杂志2014年9月第28卷第9期JChinPractDiagnTher,September2014,Vo1.28,No.9·论著·血清糖化白蛋白和同型半胱氨酸与冠状动脉病变的相关性高胜利,周秀丽,伍熙,王健,王韶屏。,王长华,张铭。,方冬平,赵东晖。(1.荣成市中医院心内科,山东荣成264300;2.首都医科大学附属北京安贞医院一blIIt管内科,北京100029)摘要:目的探讨冠状动脉病变程度与血清糖化白蛋白(glycatedalbumin,GA)、同型半胱氨酸(homocysteine,
2、Hcy)的关系及临床意义。方法行冠状动脉造影检查患者151例,依据检查结果分为冠心病组121例和非冠心病组3O例,冠心病组根据病变血管支数、Gensini积分、SYNTAX积分分为不同亚组,分析冠心病组和非冠心病组、冠心病不同亚组GA、Hcy水平差异。结果冠心病组血清GA、Hcy、高密度脂蛋白胆固醇、陈旧性心肌梗死构成比分别为(15.384-3.68)、(15.55±7.23)#mol/L、(O.93±0.22)mmol/L、18.2,非冠心病组分别为(13.88±2.0)、(12.73土4.42)tamol/L、(1
3、.O6士0.21)mmol/L、3.3,2组比较差异有统计学意义(PO.05);冠心病组Gensini积分、SYNTAX积分与血清GA、Hcy水平呈正相关(r值为0.4969~0.6731,P4、omocysteinewithcoronaryarterydiseaseGAOSheng—li,ZHOUXiu—li,WUXi,WANGJian,WANGShao—ping,WANGChang—hua,ZHANGMing,FANGDong—ping,ZHAODong—hui(*DepartmentofCardiology,RongchengTraditionalChineseMedicineHospital,Rongcheng264300,China)Abstract:0bjectiveToexplorethecorr5、elationofthelevelsofserumglycatedalbumin(GA)andhomocysteine(Hcy)withtheseverityofcoronaryarterydiseaseanditssignificance.MethodsAtotalof151patientsweredividedintocoronaryheartdisease(CHD)group(n一121)andnonCHDgroup(n一30)accordingtothecoronaryangiographyresult.CHD6、groupwasredividedintosubgroupsaccordingtothenumberoflesionvessels,GensiniscoreandSYNTAXscore,andthedifferencesofGAandHcylevelswereanalyzedamongCHD,non-CHDandsubgroups.ResultsThelevelsofserumGA,Hcyandhighdensitylipoprotein-cholesterol,andtheincidenceofoldmyocardi7、alinfarctionwere(15.38±3.68),(15.55~7.23)/~mol/L,(O.93士0.22)mmol/Land18.2%inCHDgroup,and(13.88±2.O),(12.73土4.42)~mol/L,(1.06士0.21)mmol/Land3.3innon-CHDgroup,showingsignificantdifferencesbetweentwogroups(P8、ongsubgroupswithdifferentlesionvessels(P>O.05).GensiniscoreandSYNTAXscorewerepositivelycorrelatedwiththeserumlevelsofGAandHcy(r:0.4969to0.6731,P<0.05).ConclusionJoint
4、omocysteinewithcoronaryarterydiseaseGAOSheng—li,ZHOUXiu—li,WUXi,WANGJian,WANGShao—ping,WANGChang—hua,ZHANGMing,FANGDong—ping,ZHAODong—hui(*DepartmentofCardiology,RongchengTraditionalChineseMedicineHospital,Rongcheng264300,China)Abstract:0bjectiveToexplorethecorr
5、elationofthelevelsofserumglycatedalbumin(GA)andhomocysteine(Hcy)withtheseverityofcoronaryarterydiseaseanditssignificance.MethodsAtotalof151patientsweredividedintocoronaryheartdisease(CHD)group(n一121)andnonCHDgroup(n一30)accordingtothecoronaryangiographyresult.CHD
6、groupwasredividedintosubgroupsaccordingtothenumberoflesionvessels,GensiniscoreandSYNTAXscore,andthedifferencesofGAandHcylevelswereanalyzedamongCHD,non-CHDandsubgroups.ResultsThelevelsofserumGA,Hcyandhighdensitylipoprotein-cholesterol,andtheincidenceofoldmyocardi
7、alinfarctionwere(15.38±3.68),(15.55~7.23)/~mol/L,(O.93士0.22)mmol/Land18.2%inCHDgroup,and(13.88±2.O),(12.73土4.42)~mol/L,(1.06士0.21)mmol/Land3.3innon-CHDgroup,showingsignificantdifferencesbetweentwogroups(P8、ongsubgroupswithdifferentlesionvessels(P>O.05).GensiniscoreandSYNTAXscorewerepositivelycorrelatedwiththeserumlevelsofGAandHcy(r:0.4969to0.6731,P<0.05).ConclusionJoint
8、ongsubgroupswithdifferentlesionvessels(P>O.05).GensiniscoreandSYNTAXscorewerepositivelycorrelatedwiththeserumlevelsofGAandHcy(r:0.4969to0.6731,P<0.05).ConclusionJoint
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