重组人脑利钠肽对老年充血性心力衰竭的疗效评价

《重组人脑利钠肽对老年充血性心力衰竭的疗效评价》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、KKME---专业医学搜索引擎http://www.kkme.net/重组人脑利钠肽对老年充血性心力衰竭的疗效评价　　作者：夏中华，刘　琼作者单位：桂林医学院附属医院心内科，广西桂林　541001　　【摘要】目的：研究静脉注射重组人脑利钠肽(rhBNP)治疗老年充血性心力衰竭患者的疗效。方法：118例老年充血性心力衰竭患者被随机分为：常规治疗组(56例)，给予常规药物治疗;rhBNP组(n=62)，以rhBNP1.5Μg/kg静脉注射后，再以0.0075Μg/kg连续滴注;观察两组治疗前后超声心动图变化，血浆N末端脑利钠肽前体(NT-proBNP)浓度的变化以及出院后患者主要心血管

2、事件的发生情况。结果：与治疗前比较，治疗5d后rhBNP组左室射血分数明显提高[(0.37±0.10)∶(0.44±0.09)，P<0.05];两组血浆NT-proBNP水平均有明显下降[常规治疗组(7532.7±1005.6)pg/ml∶(7056.5±998.3)pg/ml，rhBNP组(7565.1±1102.3)pg/ml∶(6206.7±1137.9)pg/ml，P<0.05]，且rhBNP治疗组下降更明显(P<0.05);两组患者治疗前后左心室舒张末期内径(LVEDd)无明显变化(P>0.05);在8个月的随访期内rhBNP组心脏不良事件少于常规治疗组(9.7%∶28.

3、6%)。结论：重组人脑利钠肽是治疗老年充血性心力衰竭的有效药物。　　【关键词】利钠肽,脑,心力衰竭,充血性,老年人　　Abstract：Objective：Tostudythetherapeuticeffectsofintravenousinjectionofrecombinanthumanbrainnatriureticpeptide(rhBNP)oncongestiveheartfailure(CHF)inagedpatients.Methods：AKKME---专业医学搜索引擎http://www.kkme.net/totalof118agedpatientswithCHFw

4、ererandomlydividedintoroutinetreatmentgroup(n=56，receivedroutinedrugtreatment)andrhBNPgroup(n=62，receivedrhBNPintravenousinjectionwith1.5Μg/kgwithin90sfollowedby0.0075Μg/kg?minivdropfor48h).ChangesofechocardiogramandplasmaconcentrationofNterminal-proBNP(NT-proBNP)beforeandaftertreatmentandinci

5、denceofmainadversecardiovascularevents(MACE)post-dischargewereobservedandanalyzedinthetwogroups.Results：Comparedwithbeforetreatment，fivedaysaftertreatmentleftventricularejectioninfractionsignificantlyincreased[(0.37±0.10)vs.(0.44±0.09)，P<0.05]inrhBNPgroup.PlasmalevelsofNT-proBNPofthetwogroupss

6、ignificantlydecreased[routinetreatmentgroup(7532.7±1005.6)pg/mlvs.(7056.5±998.3)pg/ml，rhBNPgroup(7565.1±1102.3)pg/mlvs.(6206.7±1137.9)pg/ml，P<0.05]，andit′smoresignificantinrhBNPgroup(P<0.05).Leftventricularend-diastolicdimension(LVEDd)ofthetwogroupsshowednosignificantchangesbeforeandaftertreat

7、ment(P>0.05).Duringfollowupperiodofeightmonths，rhBNPgrouphadfewercardiovascularevents(9.7%)thanroutinetreatmentgroup(28.6%).Conclusion：Recombinanthumanbrainnatriureticpeptideisaneffectivedrugfortreatmentofcongestiveheartfailureinagedpat