聚乙烯醇栓塞微球可载药微球介入治疗中晚期肝癌的临床疗效及安全性观察

《聚乙烯醇栓塞微球可载药微球介入治疗中晚期肝癌的临床疗效及安全性观察》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、聚乙烯醇栓塞微球可载药微球介入治疗中晚期肝癌的临床疗效及安全性观察徐文杰曹刚張根山厘胜利徐浩摘要：目的探宄聚乙烯醇可载药栓塞微球介入治疗中晚期肝癌的临床疗效及安全性。方法将60例中晚期肝细胞癌患者，根据患者的疾病实际情况和患者的意愿结合，随机分为对照组，治疗组和实验组，每组20例。对照组采用传统的单纯碘化油乳剂栓塞TACE术，治疗组采用碘化油乳剂+明胶海绵栓塞TACE术，实验组采用碘化油乳剂+Callispheros可载药微球栓塞TACE术，对比3组患荠HCE术后的不良反应、1个月后的肿瘤坏死率和术前、术后AFP变化。结果实验组和对照组术后不良反应较少，均少于

2、治疗组;实验组和治疗组术后1月肿瘤坏死率明显高于对照组，实验组与治疗组术后1月肿瘤坏死率相当;3组患者的术后八FP水平均明显低于术前。结论应用聚乙烯醇可载药栓塞微球+腆油对屮晚期肝癌患者行TACE术，比传统的应用碘化油的TACE术，手术效果好；比明胶海绵+碘化汕的TACE术，手术效果和当，但是其导致的并发症较少，更利于患者术后恢复。关键词：聚乙烯醇栓塞微球;微球介入;肝癌;疗效;安全性;收稿日期：2017-06-23ClinicalEfficacyandSafetyofPolyvinylAlcoholCallispheresintheInterventiona

3、lTherapyforAdvancedLiverCancerXUWeniieCAOGangZHANGGenshanLianyungangHospitalAffiliatedtoXuzhouMedicalUniversity;Abstract：ObjectiveToinvestigatetheclinicalefficacyandsafetyofpolyvinylalcoholcallispheresintheinterventionaltherapyforadvancedlivercancer.Methods60patientsdiagnosedwithadv

4、ancedhepatocellularcarcinomawererandomlydividedintothecontrolgroup,thetreatmentgroupandtheexperimentalgroup;eachwith20cases.ThecontrolgroupreceivedtraditionalTACEsurgerywithlipiodol;thetreatmentgroupreceivedlipiodol+gelatinspongeembolization,andtheexperimentalgroupreceivedcallispher

5、esmicrospheres+lipiodol.ComparedtheAFPchangesbeforeandafterTACEsurgery,adversereactionsandthetumornecrosisrateafterTACEofthe3groups-ResultsTheexperimentalgroupandthecontrolgrouphadlessadversereactionsthanthetreatmentgroup;theexperimentalgroupandthetreatmentgrouphadsignificantlyhighe

6、rtumornecrosisrate1monthafterTACEsurgerythanthecontrolgroup,andtheexperimentalgrouphasthesametumornecrosisrate1monthafterTACEsurgeryasthetreatmentgroup.TheAFPlevelofthe3groupsafterTACEwassignificantlylowerthanthatbeforeTACE.ConclusionTheapplicationofcallispheres+lipiodolinTACEhasthe

7、sameclinicalefficacyasgelatinsponge+lipiodol,buthasbetterefficacythanthetraditionaltreatmentwith1ipiodol.Cal1ispheres+lipiodolhas1esscomplications,anditisbeneficialfortherecoveryofpatientsafterTACE.Keyword：Polyvinylalcoholembolizationmicrospheres;Microspheresintervention;Livercancer

8、;Efficacy;Safety;Re