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1、FilipinLevelsasPotentialPredictorsofAlzheimer’sDiseaseRiskFilipinLevelsasPotentialPredictorsofAlzheimer’sDiseaseRiskMichaelA.Castello,KristyD.HoanAnatomy,DepartmentofPathologyandHumanAnatomy,LomaLindaUniversitySchoolofMedicine,LomaLinda,CA,USAEmail:ss
2、orianollu.eduReceived17July2014;revised20August2014;accepted28August2014Copyright©2014byauthorsandScientificResearchPublishingInc.ThisonsAttributionInternationalLicense(CCBY).creativemons.org/licenses/by/4.0/AbstractTodate,therapiestopreventortre
3、atAlzheimer’sdisease(AD)havelargelyfocusedonremovingexcessaggregation-proneamyloidpeptideAβfromthebrain,anapproachthathasproduceddisappointingclinicaloutes.AnalternativehypothesisproposesthatAβproductionandaggregationisasymptomofalarger,systemicdiseas
4、eaffectingtheregulationoflipids,includingcholesterol.Inthisscenario,lipiddysregulationakingitanidealtargetforpredictingriskofmildcognitiveimpairment(MCI)toADconversion.Here,acrolideagecausedby27-hydroxycholesterolandentiastatusinhumanperipheralbloodce
5、lls.TheseresultsprovidestrongpreliminarydatasuggestingthatfilipincouldbeofuseinthedevelopmentofaquickandinexpensivemethodtomeasuretheriskofADconversioninpatientsentingexistingtestingstrategiesthatfocusontheconsequencesofAβaccumulation.Keyer’sDisease,L
6、ipidDysregulation,Cholesterol,MildCognitiveImpairment,FilipinLevels1.IntroductionAlzheimer’sdisease(AD)isthemostmonformofdementiaintheUnitedStates,representingaroundeightypercentofallcases.Asthecountry’ssixthleadingcauseofdeath,ADcurrentlyaffects5.4mi
7、llionAmericansandisprojectedtoincreaseto7.7millionoverthenextseveraldecades[1].ConclusivediagnosisofADismadepostmortem,arksarevisualizedinthebrain:extracellularsenileplaques(SPs),prisedoftheamyloid-betapeptide(Aβ),andneurofibrillarytangles(NFTs),madef
8、romabnormallyphos-M.A.Castelloetal.138phorylatedtauprotein.Todate,ADresearchandtherapyhaslargelyfocusedonremovingexcessaggregationproneAβfromthebrain.HoerousdrugshavesuccessfullyreducedtheburdenofAβinthebrainbyremovingitorpreventingitsaggregat
