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1、Whatistheroleofplasmaviscosityinhemostasisandvasculardiseaserisk?Author:LarryHBernstein,MDandCurator:AvivaLev-Ari,PhD,RNThisisthefirstofatwopartdiscussionofviscosity,hemostasis,andvascularriskPartII: SpecialConsiderationsinBloodLipoproteins,Viscosity,AssessmentandTreatmentThesisSta
2、tement:Theeffectsof low-densitylipoprotein and high-densitylipoprotein onbloodviscositycorrelatewiththeirassociationwithriskofatherosclerosisinhumans. (Seminalstudy)G.D.Sloop,MD.DepartmentofPathology, LouisianaStateUniversitySchoolofMedicine,NewOrleans,LA 70112,U.S.A.· Increasedblo
3、odorplasmaviscosityhasbeenassociatedwithincreasedatherogenesis,andthattheeffectsoflow-densitylipoproteinandhigh-densitylipoproteinonbloodviscositycorrelatewiththeirassociationwithatherosclerosisrisk.·Low-densitylipoprotein-cholesterolwasmorestronglycorrelatedwithbloodviscositythanw
4、astotalcholesterol(r=0.4149,P=0.0281,comparedwithr=0.2790,P=0.1505).High-densitylipoprotein-cholesterollevelswereinverselyassociatedwithbloodviscosity(r=–0.4018,P=0.0341).·Toconfirmtheseeffects,viscometrywasperformedonerythrocytes,suspendedinsaline,whichhadbeenincubatedinplasmaofva
5、riouslow-densitylipoprotein/high-densitylipoproteinratios.Viscositycorrelateddirectlywithlow-densitylipoprotein/high-densitylipoproteinratio(n=23,r=0.8561,P<0.01).·Low-densitylipoproteinreceptoroccupancydatasuggeststhattheseeffectsonviscosityaremediatedbyerythrocyteaggregation.·The
6、seresultsdemonstratethattheeffectsoflow-densitylipoproteinandhigh-densitylipoproteinonbloodviscosityinhealthysubjectsmayplayaroleinatherogenesisbymodulatingthedwellorresidencetimeofatherogenicparticlesinthevicinityoftheendothelium.Thisdiscussionisanadditionalperspectiveontheserieso
7、ncoagulation,andearlierpoststhatwereonflowdynamics.StrokeandBleedinginAtrialFibrillationwithChronicKidneyDiseaseAtrialFibrillation:TheLatestManagementStrategiesOutcomesinHighCardiovascularRiskPatients:Prasugrel(Effient)vs.Clopidogrel(Plavix);Aliskiren(Tekturna)addedtoACEoraddedtoAR
8、BPositioningaTherapeuticCo
