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1、LiverTransplantationforHCCBeyondtheMilanCriteriaCharlesM.Miller,MDTheRecanati-MillerTransplantationInstituteMountSinaiMedicalCenterNewYork,NYThispresentationisreproducedonthissitewiththepermissionoftheauthor(s).Allopinions,researchcitationsandanalysesarethoseoft
2、heauthor(s)andmaynotreflectthoseofOPTN/UNOScommitteesortheOPTN/UNOSBoardofDirectors.LONGTERMRESULTSOFLIVERTRANSPLANTATIONANDMULTIMODALADJUVANTTHERAPYFORTHETREATMENTOFHEPATOCELLULARCARCINOMALARGERTHAN5CMSasanRoayaie,SukruEmre,ThomasFishbein,PatriciaSheiner,Charles
3、Miller,andMyronSchwartzTheRecanati-MillerTransplantationInstituteMountSinaiMedicalCenterNewYork,NYAnnalsofSurgeryVol.235,No.4533-539April,2002Thispresentationisreproducedonthissitewiththepermissionoftheauthor(s).Allopinions,researchcitationsandanalysesarethoseoft
4、heauthor(s)andmaynotreflectthoseofOPTN/UNOScommitteesortheOPTN/UNOSBoardofDirectors.Background:HCCmostcommonsolidorgantumorworldwideonemilliondeathsannuallyincidencerisinginUS2.4per100,000goodsurvivalwithtransplantfortumors5cm75%at4yearspoorsurvivalwithtransplan
5、tfortumors5cm18-30%at5yearsThispresentationisreproducedonthissitewiththepermissionoftheauthor(s).Allopinions,researchcitationsandanalysesarethoseoftheauthor(s)andmaynotreflectthoseofOPTN/UNOScommitteesortheOPTN/UNOSBoardofDirectors.PreviousStudiesThispresentatio
6、nisreproducedonthissitewiththepermissionoftheauthor(s).Allopinions,researchcitationsandanalysesarethoseoftheauthor(s)andmaynotreflectthoseofOPTN/UNOScommitteesortheOPTN/UNOSBoardofDirectors.CandidateEntryCriteriaunresectableHCC5cmfreeofextrahepaticdiseaseCTchest
7、,abdomen&pelvisbonescanpatentmajorhepatic&mainportalveinsmulticentrictumorsnotexcludedlargesttumorinlessinvolvedlobe<5cmtumorinvolving<75%parenchymaThispresentationisreproducedonthissitewiththepermissionoftheauthor(s).Allopinions,researchcitationsandanalysesareth
8、oseoftheauthor(s)andmaynotreflectthoseofOPTN/UNOScommitteesortheOPTN/UNOSBoardofDirectors.EntryCriterianosignificantascitesorencephalopathyINR<1.5creatinine<2m