酒精性肝硬化患者血清脂肪因子的临床意义分析

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1、酒精性肝硬化患者血清脂肪因子的临床意义分析　　[摘要]目的探�酒精性肝硬化患者血清脂肪因子的临床意义。方法将2014年3月～2016年3月于河北省沧州市中心医院住院治疗的52例酒精性肝硬化患者作为肝硬化组，其中Child-Pugh分级A级17例，B级20例，C级15例；同时选择32名健康体检者作为对照组。检测并比较肝硬化组及不同Child-Pugh分级的肝硬化患者与对照组的血清网膜素、脂联素、内脏脂肪素及其他相关的临床生化参数；采用Spearman等级相关分析法及线性回归方程分析酒精性肝硬化患者血清脂肪因子与各生化指标的相关性。结果肝硬化组患者血清网膜素、脂联素水平分别为（925.19±16

2、7.58）ng/L和（908.06±156.96）μg/L，明显高于对照组[（793.68±100.38）ng/L、（649.97±105.01）μg/L]（P0.05），而随着Child-Pugh分级A、B、C级的逐渐增高，肝硬化组患者的HOMA-IR和IL-6水平也逐渐升高（P0.05）。结论肝硬化时网膜素、脂联素升高，内脏脂肪素下降，其可作为预测肝硬化的指标，但不能作为肝功能严重程度的评估指标[关键词]酒精性肝硬化；网膜素；脂联素；内脏脂肪素；Child-Pugh分级；胰岛素抵抗10[中图分类号]R575.5[文献标识码]A[文章编号]1674-4721（2016）11（a）-0018

3、-04AnalysisofclinicalsignificanceofserumadipocytefactorsofpatientswithalcoholiccirrhosisWEIXin-liangWEISi-chenTIANShu-yingKONGYuWANGWei-weiJIANGHong-yuDeparmentofGastroenterlogy，theCentralHospitalofCangzhouCity，HebeiProvince，Cangzhou061001，China[Abstract]ObjectiveToinvestigatetheclinicalsignificanc

4、eofserumadipocytefactorsinpatientswithalcoholiccirrhosis.Methods52patientswithalcoholiccirrhosisfromMarch2014toMarch2016intheCentralHospitalofCangzhouCitywereselectedaslivercirrhosisgroup，amongwhich17casesofclassAofChild-Pughgrading，20patientswithclassB，15casesofgradeC；and32healthycontrolswereselec

5、tedascontrolgroupatthesametime.Levelsofserumomentin，adiponectin，visfatinandotherrelatedclinicalandbiochemicalparametersweremeasuredandcomparedbetweenpatientswithlivercirrhosis，differentChild-Pughclassofliver10cirrhosisandcontrolgroup.Spearmanrankcorrelationanalysisandequationoflinearregressionwereu

6、sedtoanalyzedtherelationshipbetweencirrhosisserumfatfactorsandtherelatedbiochemicalindicatorsofpatientswithalcoholicliver.ResultsThelevelsofserumomentinandadiponectininthelivercirrhosisgroup[（925.19±167.58）ng/L，（908.06±156.96）μg/L]weresignificantlyhigherthanthoseofthecontrolgroup[（793.68±100.38）ng/

7、L，（649.97±105.01）μg/L]（P0.05）.AstheincreaseofChild-Pughgrading，thelevelsofgroupofinsulinresistanceindexandIL-6increasedgraduallyinpatientsofthelivercirrhosisgroup（P　　[Keywords]Alcoholiccirrhosis；Omentin；Adi