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时间:2020-05-02
《右美托咪定对子宫肌瘤切除术患者全麻苏醒期应激反应的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、ProgressinModernBiome~cmeVoL14No.24AUG2014·4757·doi:10.13241/j.cnki.pmb.2014.24.041右美托咪定对子宫肌瘤切除术患者全麻苏醒期应激反应的影响许站杨洋刘霞满元元L△郭晓东。(1解放军总医院麻醉手术中心北京100853;2河南省南阳市骨科医院麻醉科河南南阳473054;3解放军第302医院北京100039)摘要目的:探讨盐酸右美托咪定用于全凭静脉麻醉对子宫肌瘤切除术患者应激反应的影响。方法:选择我院收治的择期行子宫肌瘤切除术患者6
2、0例,随机分为观察组和对照组,每组30例。两组患者均采用全麻,其中观察组患者在麻醉诱导15min内静脉输注lug/kg盐酸右美托咪定注射液,术中0.3—0.6ug/(kg~h)维持;而对照组患者采用静脉输注0.9%的Nacl溶液。分别于麻醉前、麻醉后及苏醒期测定并观察两组患者外周静脉血中TNF.o/.,IL.2和IL.6的浓度变化情况。结果:两组患者麻醉前TNF—a,IL一2和IL-6的浓度无显著性差异(P>0.05)。两组患者麻醉后及苏醒期TNF—,IL一2及IL.6浓度均显著高于麻醉前,差异具有统计学
3、意义(P<0.05)。观察组患者麻醉后及苏醒期TNF-0l,IL一2及IL一6浓度均显著低于对照组,差异具有统计学意义(P<0.05)。结论:右美托咪定用于全凭静脉麻醉对子宫肌瘤切除术患者血清TNF一、IL一2和IL,6浓度具有调节作用,可缓解或降低手术引起的应激反应。关键词:盐酸右美托咪定;子宫肌瘤切除术;应激反应;全凭静脉麻醉中图分类号:R614文献标识码:A文章编号:1673.6273(2014)24.4757.03EffectsofDexmedetomidineOntheStressReactio
4、nsofIntravenousAnesthesiaforPatientswithHysteromyomectomyXUZhd,YANGYang2,LIUXia3,MANYuan-yuaf~,GUOXiao—dongJ(1AnesthesiaSurgeryCenter,GeneralHospitalofPLA,Beijing,100853,China;2DepartmentofAnesthesiology,NanyangOrthopaedicHospitalofHenanProvince,Nanyang,4
5、73054,China;3Beijing302Hospital,Beijing,10003~China)ABSTRACTObjective:Todiscusstheefectsofdexmedetomidineonthestressreactionsofintravenousanesthesiaforpatientswiththehysteromyomectomy.Methods:60patientswhowereundergoingthehysteromyomectomyinourhospitalwer
6、eselectedandrandomlydividedintotheobservationgroupandthecontrolgroupwith30casesineachone.Allthepatientsweretakentheintravenousanesthesi-a.Thepatientsintheobservationgroupwereinducedbythedexmedetomidinehydrochlorideinjectionwith1ug/kgin15min.andkeptintheop
7、erationwith0.3—0.6ug/kg(h).Whilethepatientsinthecontrolgroupweretreatedbytheintravenousinfusionwith0.9%Nac1.ThentheconcentrationsofTNF-o/.,IL-2andIL一6intheserumofpatientsbeforetheanesthesia,aftertheanesthesiaandtherecoveryweredetectedandcompared.Results:T
8、herewasnostatisticallysignificantdiferenceabouttheconcentrationsofTNF—d.IL一2andIL一6ofpa—tientsinthetwogroupsbeforetheanesthesia(P>0.05).TheconcentrationsofTNF·o【.IL-2andIL-6ofpatientsaftertheanesthesiaandintherecove
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