临床医学论文老年急性白血病的临床特点及免疫学表型的研究

《临床医学论文老年急性白血病的临床特点及免疫学表型的研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、临床医学论文-老年急性白血病的临床特点及免疫学表型的硏究【摘要】本硏究分析老年急性白血病(AL)临床特点及生物学特征。对经FAB确诊的104例老年AL的临床及牛物学特征进行回顾性分析，同时以71例非老年AL为对照并进行比较。结果表明：①老年急性非淋巴细胞性白血病(AML)比例(73%)明显多于非老年急性非淋巴细胞性口血病(AML)比例(54.9%)，差别有统计学意义(P<0.05)，本组老年AML(M3)缺如；②老年AL骨髓原始细胞中位数明显低于非老年组(P<0.05)；③AML中，老年组CD14表达率(18.8%)明显高于非老年组CD14表达率(2.6%)，老年组CD1

2、5(37.5%)、CD117C62.5%)638(59.4%)表达率低于非老年组CD15C69.2%)€0117(89.7%)、CD38(84.6%)表达率，差别均有统计学意义(P<0.05):④老年组急性淋巴细胞性白血病(ALL)中CD19表达最常见，表达率为100%；⑤老年组与非老年组在系列抗原专一表达和交叉表达及CR率上差别无显著性(P〉0・05)；⑥老年组不良核型表达率高于非老年组，差异有显著性(PV0.01);⑦老年组完全缓解率(CR率)为42.9%»两年存活率为5.4%，化疗相关死亡率为26.8%非老年组CR率为76.6%，两组比较差异有显著性(P<0.05)

3、。结论：老年AL不良免疫分型CD14表达率较非老年组高，良好免疫分型CD15表达率低于非老年组。不良核型表达率高于非老年组，总体缓解率低〃Ell率高，化疗耐受性差，预后差。【关键词】急性白血病老年急性白血病临床特点免疫表型ClinicalCharacteristicsandImmunophenotypeofAgedPatientswithAcuteLeukemiaAbstractInordertoanalyzetheclinicalcharacteristicsandbiologicalfeaturesofacuteleukemiainelderly,104acutele

4、ukemiapatientsinelderlywereretrospectivelyanalyzedandcomparedwith71acuteleukemiapatientsbelow60yearsold.Theresultsshowedthat:(1)theproportionofAMLintheagedgroup(73%)washigherthanthatintheyounggroup(54.9%),andthedifferencewasstatisticallysignificant(P<0.05),butAML(M3)wasabsentintheagedgrou

5、p;(2)themedianofbonemarrowblastcellintheagedgroupwassignificantlylowerthanthatintheyounggroup(P<0.05);(3)inAML,thefrequentlyofCD14expressionwashigherintheagedgroup(18.8%)thanthatintheyounggroup(2.6%),whiletheexpressionfrequenciesofCD15(37.5%),CD117(62.5%),andCD38(59.4%)wererespectivelylow

6、erintheagedgroupthanthatintheyounggroupwhichwere(69.2%)forCD15,(89.7%)forCD17,and(84.6%)forCD38respectively,andthedifferencewasalsostatisticallysignificant(P<0.05)・(4)CD19wasmostfrequentlyexpressedinALLoftheagedgroupandthepositiveratewas100%;(5)therewasnosignificantdifferenceinexpressiono

7、fspeciallineageantigensandoverlappinglineageantigensbetweentheagedgroupandtheyounggroup(P>0.05);(6)theexpressionfrequencyofunfavorablekaryotypesintheagedgroupwashigherthanthatintheyounggroup,andthedifferencewasstatisticallyverysignificant(P<0.01);(7)thecompleteremis