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时间:2017-11-30
《不同透析方法对移植肾功能延迟恢复的影响》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第26卷第1期西安交通大学学报(医学版)Vol.26No.12005年2月JournalofXi'anJiaotongUniversity(MedicalSciences)Feb.2005不同透析方法对移植肾功能延迟恢复的影响李大庆,田晓辉,蒋红利,丁小明,燕航,薛武军(西安交通大学第一医院肾病中心,陕西西安710061)摘要:4的比较不同透析方法对肾移植后肾功延迟恢复(DGF)的影响,以期选择合适的透析方法,提高移植效果。方法观察应用不同透析方法治疗DGF患者时血压、细胞因子的变化和疗效。A果采用高容量血液滤过(HVHF)治疗过程中低血压发生率4.85%a,肾功能恢复
2、时间(9.1士4.3)d,术后感染发生率9.52%,均较血液透析(HD)组低〔低血压发生率7.800,肾功能恢复时间(21.4士7.6)d,术后感染发生率2000];腹膜透析组低血压发生率6.250o,肾功能恢复时间(15.5士6.7)d,术后感染发生率37.5%,后两项指标高于HVHF组;HVHF组治疗后,TNF-a,IL-1p和IL-6的水平较治疗前明显下降,而HD组治疗前后无明显差异。结枪高容量血液滤过是一种较好的治疗DGF的方法。关键词:血液透析;高容量血液滤过;腹膜透析;肾移植;功能延迟恢复中图分类号:R617文献标识码:A文章编号:1671-8259(200
3、5)01-0064-04ClinicalstudyofbloodpurificationinthetreatmentofdelayedgraftfunctionafterrenaltransplantationLiDaging,TianXiaohui,JiangHongli,DingXiaoming,YanHang,XueWujun(RenalDiseaseCenter,FirstHospitalofXi'anJiaotongUniversity,Xi'an710061,China)ABSTRACT:ObjectiveTocomparetheeffectsofthedi
4、fferentbloodpurificationmethodsonthetreatmentofdelayedgraftfunction(DGF)afterrenaltransplantation.MethodsDuringtheperiodfromJanuary1998toJune2003,atotalof54patientsreceiveddifferentmethodsofbloodpurificationforDGFmanagement.Highvolumehemofiltration(HVHF)wasappliedto21casesinHVHFgroup,hem
5、odialysis(HD)to25casesinHDgroup,andperitonealdialysis(PD)to8casesinPDgroup;andtheeffectsofthosemethodswerecompared.ResultsAltogether,103timesofHVHF,118timesofHDand112timesofPDwereperformed.TheincidenceofhypotensionintheHVHFgroup(4.85%)andthePDgroup(6.25%)waslowerthanthatintheHDgroup(17.8
6、%)(P<0.01).Systolicbloodpressure(SBP)ofthecasesinHVHFandPDgroupsshowedslighterchangesthanthatofthecasesinHDgroup(SBP)20mmHg:20.39%,19.64%vs.27.12%;SBP)40mmHg:16.5%,18.75%vs.22.03%;SBP)60mmHg:0%a,1.79%vs.14.41%)(P<0.01).ThegraftfunctionrecoveryperiodofHVHFgroupwasshorterthanthatoftheHDand
7、PDgroups(9.1士4.3dvs.21.4士7.6d,15.5士6.7d)(P<0.01).TheincidenceofpostoperativeinfectionintheHVHFgroup(9.52%)waslowerthanthatintheHDgroup(20%)andPDgroup(37.5%)(P<0.01).AfterHVHF,thelevelofTNF-a,IL-1(3andIL-6wasdecreasedremarkablythanbefore.ConclusionComparedwithHDandPD,HVHFi
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