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ID:18245417
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时间:2018-09-15
《羧甲基茯苓多糖对小鼠t淋巴细胞分泌细胞因子的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、中药药理与临床2006;22(3、4)71phologyofcerebralcorticalarteriolesaftershort-termdiabetesinadultrats.beticrats.Diabetoligia,1993;36(10):926~930BloodVessels,1985;22(6):265~27711段文卓,宫海民,王家富,等.高糖、高脂血症大鼠血管内皮细胞及10LinSJ,HongCY,ChangMS,etal.Increasedaorticendothelialdeath平滑肌细胞的形态和功能改变.基础医学与临床,2000;20(4):
2、349~andenhancedtransendothelialmacromoleculartransportinstreptozotocin-dia-351TheprotectiveeffectofGinkgobilobaextractonvascularpathologyindiabeticaorta111YeChungling,ZhuangLan,LuChaoxia,TangFuxing,GuoZuwen,CaoShuiliang1(DepartmentofPharmacology,PharmacyCollege;LaboratoryofElectronMicros
3、copy,JinanUniversity,Guangzhou510632)Aim:ToinvestigatetheeffectofGinkgobilobaextractEGB50onpathologicalchangeofaortaultrastructureoftype2diabetesmellitus(DM)inducedbyadietrichinhighfatandsucrose.Methods:Fluorospectrophotometer,radioimmunoassayandtransmissiontelescope(TEM)wereemployedtost
4、udythechangeofserumadvancedglycosylationendproduct(sAGEs),insulin,glucose,cholestero(lCHOL),triglycerid(eTRIG),andultrastructureofaorta.Results:After5weeksˊoral-treatment,theconcentrationofCHOL,TRIG,Glycosylatedhe-moglobin,AGESdecreasedinEGB50groupatdoseof150mg/kgcomparedwithDMgroup.From
5、ultrastructureofdiabeticthoracicaorta,thenumberofvacuolesincellplasmaincreased,themitochondriaswollenweresevere,themonocytewasadhesiveontheendotheliumandmitochondriaandroughendoplasmicreticulesinthevascularsmoothmusclecellincreased.Thebiochemicalindexesandtheultrastructurehaveimproveddis
6、tinctlyinEGB50higherdosebutnotlowerdose(50mg/kg).Conclusion:EGB50iscapableofdecreasinghyperlipi-demia,theconcentrationofglycosylationproducts,thusreducestheimpairmentoftheoxidantstoendotheliumcellsofvesselsandimprovespathologicalchangeofaortaofdiabetesmellitus.KeywordsGinkgobilobaextract
7、;diabetesmellitus;aorticultrastructure;AGES羧甲基茯苓多糖对小鼠T淋巴细胞分泌细胞因子的影响#刘媛媛,陈友香,侯安继(武汉大学中南医院中西医结合科,武汉430071)摘要目的:探讨羧甲基茯苓多糖(CMP)对小鼠T淋巴细胞分泌IFN-γ、IL-10的影响。方法:CMP溶液给小鼠腹腔注射,10天后取外周血分离T细胞,体外将不同浓度的CMP与T细胞共培养,MTT法观察其对T细胞的毒性作用,ELISA法检测IFN-γ、IL-10的含量。结果:CMP在0~500µg/ml对小鼠T细胞无明显毒性作用,CMP能
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