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1、肝动脉化疗栓塞在预防原发性肝癌术后复发中的作用张岳林孙军辉聂春晖陈黎明章丽霞蔡丽霞何健娣王伟林郑树森(通讯作者)(浙江大学医学院附属第一医院肝胆胰外科及器官移植重点实验室浙江杭州310003)【】目的探讨肝动脉化疗栓塞术(TACE)对原发性肝癌(HCC)根治术后抗复发作用。方法回顾性收集2008年1月至2009年7月间HCC根治术后未接受预防性TACE的患者40例(对照组)和术后接受一次预防性TACE的患者27例(治疗组),治疗组患者在术后1-2月给予一次预防性TACE。全部病例在根治术后随访36-40个月,对比分析两组间的累计复发率。结果HCC根治术后,对照组1,2,3年累计复发率
2、分别为57.5%,65.0%,67.5%;治疗组1,2,3年累计复发率分别为29.6%,33.3%,33.3%。统计学分析治疗组1、2、3年复发率均明显低于对照组(P=0.019、P=0.012、P=0.008)。治疗组TACE术后反应较轻,患者均可耐受,未出现严重并发症。结论HCC根治术后给予一次预防性TACE在临床应用上是可行、安全、有效的,可明显降低术后复发率。【关键词】原发性肝癌化疗栓塞肿瘤复发根治性切除【】R73-3【】A【】2095-1752(2013)03-0132-03RoleofTranscatheterArterialChemoembolizationonPrev
3、entingRecurrencefollowingRadicalResectionforHepatocellularCarcinomaYue-linZHANG,Jun-huiSUN,Chun-huiNIE,Li-mingCHEN,Li-xiaCAI,Jian-diHE,Li-xiaZHANG,Wei-linWANG,Shu-senZHENGDivisionofHepatobiliaryandPancreaticSurgery,DepartmentofSurgeryFirstAffiliatedHospital,SchoolofMedicine,ZhejiangUniversity,K
4、eyLaboratoryofCombinedMulti-organTransplantation,MinistryofPublicHealthKeyLaboratoryofOrganTransplantation,ZhejiangProvince,Hangzhou310003,China[Abstract]ObjectiveToexploretheclinicalefficacyoftranscatheterarterialchemoembolization(TACE)onpreventingpostoperativerecurrenceofhepatocelularcarcinom
5、a.MethodsAtotalofconsecutive67postopetativepatientswithhepatocellularcarcinoma(HCC)fromJanuary2008toJuly2009werecollectedretrospectively.ThepatientsweredividedintotwogroupsaccordingreceivingTACEornot:thecontrolgroup(n=40)withoperationonlyandthestudygroup(n=27)withreceivingoneprophylacticTACEat1
6、-2monthsafteroperation.Allcaseswerefollowedupfor36to40monthsaftersurgery.Theratesofcumulativerecurrencebetweentwogroupswascompared.ResultsThe1-,2-and3-yearcumulativerecurrentratesincontrolgroupwere57.5%、65.0%、67.5%respectively,whileaswere29.6%,33.3%,33.3%inthestudygroup,respectively.Statistical
7、analysisshowedthatrelapseratewaslowerinthecontrolgroupthaninthestudygroupin1,2,3years(P=0.019、P=0.012、P=0.008).LiverfunctiondamageofallpatientsinthestudygroupwereminimalafterTACEandnoseriouscomplicationsoccurred.ConclusionForhepat