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1、中国科技论文在线http://www.paper.edu.cnPharmacokineticsofTerminaliaPhenolicsinRatsafterOralAdministrationofaMongolianCompoundMedicine#5Alatan-5**WuDandan,AzzayaJukov,MaChaomei(SchoolofLifeSciences,InnerMongoliaUniversity,Huhhot010021)Abstract:Thispaperreportsthepharmacoki
2、neticpropertiesofTerminaliaphenolicsafteradministrationofAlatan-5whichisacompoundMongolianmedicinecontainingthefruitofT.chebula10incombinationwithfourothermedicines.Gallicacid,ellagicacid,casuarinin,andchebulicacidweredetectedandquantifiedintheratplasma.Gallicacid
3、showedthelargestAUCvalueamongthesefourconstituentswhenAlatan-5wasadministrated,anditsAUCvaluewaslargerthanwhenT.chebulafruitwasusedalone.WhiletheAUCvaluesoftheotherconstituentsweresmallerwhenAlatan-5wasusedthanwhenT.chebulafruitwasadministratedalone.Thesedataindic
4、atedthatgallicacidandother15TerminaliaphenolicscouldplayimportantrolesinthepharmacologiceffectsofAlatan-5andthatothermedicinesinthiscompoundMongolianmedicinecouldgreatlyalterthepharmacokineticbehaviorsofTerminaliaphenolics.Keywords:TraditionalMongolianmedicines;Al
5、atan-5;Terminaliaphenolics;Pharmacokinetics200IntroductionAlatan-5isacompoundMongolianmedicinecomposedofthefruitofTerminaliachebulaRets.(400g),thefruitofPunicagranatumL.(100g),theprocessedseedofMomordicacochinchinensis(Lour.)Spreng.(40g),thefecesofTrogopterusxanth
6、ipes(110g),andthefecesofSusscrofaL.(310g).ThepowderofthiscompoundMongolianmedicineisclinicallyusedasa[1].25digestionaidandforliverdiseasesThisresearchwascarriedouttoinvestigatethepharmacokineticbehaviorstheTerminaliaphenolicsafteroraladministrationofAlatan-5torats
7、.1Experimental1.1ChemicalsandreagentsHPLCgrademethanolwasfromFisherScientific(FairLawn,NJ,USA).Formicacidwas30fromAlfaAesar,UK.GallicacidandellagicacidwerefromSigma-Aldrich(China).Casuarinin[2]andchebulicacidwereisolated,purifiedandidentifiedasdescribedinourpublis
8、hedpaper.The[3]4β-(L-acetylcysteinyl)-epicatechinpreparedinourpreviousworkwasusedasaninternalstandard(I.S.).ThepurityofthesestandardcompoundsandI.S.were
