dme临床科研设计与评价转化医学和精准医学translational medicine.pptx

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1、TranslationalMedicine&PrecisionMedicine转化医学和精准医学广东省肺癌研究所GuangdongLungCancerInstitute《循证医学》杂志JournalofEvidence-basedMedicineClinicalResearch:NIHDefinitionEpidemiologicandbehavioralstudiesOutcomesresearchandhealthservicesresearchPatient-orientedresearch-Researchconductedwithhumansubjects,tissues,spe

2、cimens,orcognitivephenomenaforwhichaninvestigatordirectlyinteractswithhumansubjectsHealthyvolunteer:personwithnoknownsignificanthealthproblemwhoparticipatesinclinicalresearchtotestadrug,device,orinterventionClinicalTrialsAprospectivestudyinvolvinghumansubjectsthatisdesignedtoanswerspecificquestions

3、abouttheeffectsorimpactofparticularbiomedicalorbehavioralinterventionsNOThealthyvolunteerstudies,whicharedesignedtodevelopnewknowledge,butprovidenodirectbenefitstothesubjectsTranslationalResearch:NIHDefinitionTheprocessofapplyingdiscoveriesgeneratedduringresearchinthelaboratory,andinpreclinicalstud

4、ies,todevelopmentoftrialsandstudiesinhumansLeveragingtheobservationsmadeinclinicalpracticetodrivenewmechanisticinvestigationsatthebenchEnhancingtheadoptionofbestpracticesinthecommunityBackgroundInthepast30years，NCI$200BillionsResults：1.56millionarticles80％onmice,fruitflyandroundworm。Nochangeoncance

5、rrelatedmortalityrateBackgroundBackgroundNewbiotechnologyGenomics(基因组),Proteomics(蛋白质组)Bioinformatics(生物信息学)IncreasingcomplexityofclinicalresearchDefinitionTranslationalresearch,“transformsscientificdiscoveriesarisingfromthelaboratory,clinical,orpopulationstudiesintoclinicalapplications…”Include：be

6、nchtobedside(基础研究到临床应用)bedsidetobench(临床治疗结果促进基础研究)Source:NationalCancerInstitute,NationalInstitutesofHealthBasicandClinicalResearchareInterdependentTranslationfrombasicsciencetohumanstudiesTranslationofnewknowledgeintoclinicalpracticeBasicResearchClinicalResearchImprovedHealthAdaptedfromSungetal.(

7、2003)JAMA,289,1278-89.Copyright©(2003)AmericanMedicalAssociation.AllRightsreserved.“T1”“T2”Theproductionofapromisingnewtreatment/methodthatcanbeusedclinicallyorcommercialized.Ensurethatnewtreatmentsandresea