花椒麻味素剂量对SD雌性大鼠肠道健康的影响.pdf

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1、营养与僳馋ScienceandTechnologrofFoodIndustry花椒麻味素剂量对SD雌性大鼠肠道健康的影响叶敏。吕娇，任文瑾，刘雄(西南大学食品科学学院，重庆400715)摘要：目的：研究不同花椒麻味素灌喂剂量对大鼠肠道健康的影响。方法：将40只SD雌性大鼠按体重随机将大鼠分为空白组(LOD)，高脂组即高脂空白组(HF—LOD)、高脂并灌胃4rag／kg／d(HF—CD)、高脂并灌胃8mg／kg／d(HF—MD)、高脂并灌胃12mg／kg／a(HF—HD)花椒麻味素的大豆油溶液等共5组各8只。饲养期间自由采食基础饲料和饮水，喂养4

2、周后解剖，测定盲肠质量、盲肠内容物、盲肠组织重量、盲肠内容物游离氨以及盲肠中短链脂肪酸和微生物。结果：高脂空白组与空白组相比，采食量、饲料效率和盲肠面积显著增加，双歧杆菌显著降低；高脂空白组与剂量组相比，各剂量组的体重增加量、饲料效率、乳酸茵、厌氧茵和双歧杆菌显著增加，盲肠面积显著降低，中剂量组的丙酸、异丁酸、总的SCFAs显著增加，肠球菌显著降低，中、高剂量组的大肠杆菌显著降低。结论：高脂饲料会延长饲料在消化道的时间，抑制肠道有益菌的生长，花椒麻味素能够改善由高脂饲料引起的各种肠道不良反应，促进肠道发酵和有益菌的生长。关键词：花椒麻味素，肠道

3、健康，短链脂肪酸，游离氨，微生物EffectsofsanshooIontheintestinalhealtheffectsoffemaleSprague-DawleyratsYEMin，LVJiao，RENWen—jin，LIUXiong(CollegeofFoodScience，SouthwestUniversity，Chongqing400715，China)Abstract：Objective：Tostudytheeffectofdifferentdoseofsanshoolonrats’intestinalhealth．Methods：

4、40femaleSDratswererandomlydividedinto5groupsof8accordingtotheweight，whichincludedcontrolgrouprats(LOD)，high—fatgroupnamelyblankgroup(HF-LOD)，high-fatfed4mg／kg／d(HF—CD)，high—fatfed8mg／kg／d(HF—MD)，high—fatfed12mg／kg／d(HF—HD)SanshoolSolubledinSoybeanoil．Duringthefeeding，feedand

5、waterintakefreely，after4weeksoffeeding，cecumquality，cecalcontents，cecaltissueweight，cecalcontents，freeammonia，shortchainfattyacidsandmicroorganisminthececumweredetermined．Results：Contrastedwithblankcontrolgroup，feedintake，feedefficiencyandcecalareainhigh-fatgroupincreasedsig

6、nificantly，bifidobacteriumsignificantlyreduced．Comparedwiththecontrolgroup，eachdoseoftheweightgain，feedefficiency，lacticacidbacteria，anaerobicbacteriaandbifidobacteriaofthehigh—fatgroupincreasedsignificantly，thececalareasignificantlyreduced，propionicacid，isobutyricacid，total

7、SCFAsinthemiddledosegroupincreasedsignificantly，enterococcisignificantlyreduced，E．coliinthemiddleandhighdosegroupsignificantlyreduced．Conclusion：High—fatdietwillextendthedigestionandinhibitthegrowthofintestinalbacteria，Sanshoolcanimproveavarietyofintestinalbadreactionscaused

8、bythehighfatdietandpromoteintestinalfermentationandthegrowthofbeneficialbac