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1、临床医学论文•肾活检1542例临床病理资料分析作者：杜娟丽，王汉民，于艳，连耀国，陈威，张静，刘彦仿【关键词】肾脏疾病；肾;活组织检查；病理类型；回顾性分析Analysisonclinicopathologicaldataof1542casesundergoingrenalbiopsy[Abstract]AIM:Toinvestigatetherelationbetweenrenalpathologicalcategoryandclinicalfeaturesbyanalyzingtheclinicopathologicaldatein1542c
2、aseshavingunderwentrenalbiopsy.METHODS:PathologicalclassificationsweremadeaccordingtotheWHOcriteriaof1982forrenalpathologyorthemodifiedWHOcriteriaof1995andtheclinicaldata,laboratoryresults,lightmicroscopy,immunefluorescenceandelectronmicroscopybyapanelofpathologistsandnephrol
3、ogistsinroutineclinicalpathologicalrounds•RESULTS:Theaverageageatrenalbiopsywas32.5±15.3(6-63)yearsoldin1542patientswithrenaldiseases,andtheratioofmaletofemalewas1.55-1.Primaryglomerulardiseases(PGD)accountedfor69.39%,secondaryglomerulonephritis(SGN)for26.85%,andendstagerenal
4、disease(ESRD)for2.59%.ThePGDindescendingorderofincidence,weremesangialproliferaliveglomerulonephritis(MsPGN,45.05%),focalsegmentalglomerulosclerosis(FSGS,16.73%)andIgAnephropathy(8.32%).TheSGNindescendingorderofincidence,werelupusnephritis(14.27%),purpuranephritis(7.00%)andhe
5、patitisBvirusassociatednephritis(HBVGN,1.95%).Thechronicrenalfailureindescendingorderofincidence,wereTgAnephropathy(13.70%),proliferalivesclerosingglomerulonephriIis(PSGN,10.40%)andFSGS(9.10%).CONCLUSION:Inourarea,renaldiseasesoftenhappeninyoungpeople.PGDisadominatingtypeinwh
6、ichMsPGNisthemostcommon.IntheSGN,lupusnephritisisdominant.ThemajorpathologicalcategoriesofthecausesofchronicrenalfailureareTgAnephropathyandPSGN.[Keywords]renaldisease;renal;biopsy;pathologicalcategory;retrospectiveanalysis【摘要】目的：回顾性分析1542例因肾脏疾病行经皮肾活检患者的病理类型和临床资料并探讨二者之间的联系.方法
7、：参照阳0(1982年及改良的1995年)肾小球疾病组织学分型方案，结合临床资料、实验室检查结果、光镜、免疫病理及电镜的改变特点，提出初步诊断，最后与临床医师共同讨论确定诊断.结果：患者行肾活检时平均年龄32.5±15.3(6~63)岁，男女之比为1.55:1.原发性肾小球疾病占首位(69.39%)，继发性肾小球疾病占26.85%，终末期肾病占2.59%.原发性肾小球疾病的病理类型中最多见为系膜增生性肾小球肾炎(45.05%)，其次为局灶节段性肾小球硬化症(16.73%)和IgA肾病(8.32%),继发性肾小球疾病以狼疮肾炎居首位(14.27%)
8、，其次为紫瘢性肾炎(7.00%)和乙肝相关性肾炎（1.95%）.引起慢性肾功能不全的病理类型依次为IgA肾病（13.70%）、增生硬化性
