老年脓毒症患者并发肝功能不全的危险因素分析.pdf

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1、主里垦卫蕉堡墨查兰笙旦!鲞第l7期ChinJPostgradMed，June152014，V。1．37，N。．17·1·临床论著·老年脓毒症患者并发肝功能不全的危险因素分析翁志雄余志金龙国清叶初阳陈惠新刘志红I摘要】目的探讨老年脓毒症患者并发肝功能不全的危险因素。方法采用病例一对照研究方法入选384例老年脓毒症患者，其中住院期间发生肝功能不全91例(病例组)，未发生肝功能不全293例(对照组)，对各种可能导致肝功能不全的相关危险因素进行单因素和多因素Logistic回归分析。结果单因素分析结果显示，年龄

2、、饮酒史、慢性基础病、动脉血乳酸、机械通气和急性生理学与慢性健康状况评分Ⅲ(APACHE一11I)是老年脓毒症患者并发肝功能不全的危险因素(P

3、actorsanalysisonsepsiscomplicatedwithhepaticinsufficiencyinelderpatientsWengZhixiong，YuZhijin，LongGuoqing，YeChuyang，ChenHuixin，LiuZhihong．DeportmentofMedicalEmergencyandWoundCenter，theCentralPeople’sHospitalofHuizhou，GuangdongHuizhou516001，ChinaCorrespon

4、dingauthor：WengZhixiong，Email：hencyO07@163．com【Abstract】ObjectiveToexploretheriskfactorsofsepsiscomplicatedwithhepaticinsufficiencyinelderpatients．MethodsWithretrospectivecase—controlstudymethod，accordingtowhetherornotcomplicatedwithhepaticinsuficiency，a

5、totalof384eldersepsispatientsweredividedintocasegroup(91patients)andcontrolgroup(293patients)，thensinglefactoranalysisandmuhiplefactorsLogisticregressionmethodswereusedtoscreentheriskfactors．ResultsSinglefactoranalysisidentified6kindsofsignificantvariabl

6、es．includingage(P=O．000)，historyofalcohol(P=0．006)，chronicdiseases(P=0．001)，arterialbloodlactatelevel(P=0．035)，mechanicalventilation(P：0．009)andacutephysiologyandchronichealthevaluationmscore(APACHE．11I)scores(P=0．0O4)．MultiplefactorsLogisticregressionan

7、alysisshowedthatage．historyofalcohol，chronicdiseases，aaefialbloodlactatelevel，mechanicalventilation，APACHE—IUscoreswerecorrelatedwithsepsiscomplicatedhepaticinsuficiencyinelderpatients(P<0．01or<0．05)．ConclusionTheriskfactorswhichcloselyrelatetosepsiscomp

8、licatedwithhepaticinsuficiencyinelderpatientsareage，historyofalcohol，chronicdiseases，arterialbloodlactatelevel，mechanicalventilation，APACHE—IIIscores．【KeywordslAged；Sepsis；Hepaticinsugiciency；RiskfactorsDOI：10．3760／cma．j．i