经肝动脉化疗栓塞联合射频消融治疗肝细胞癌疗效荟萃分析.pdf

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1、．-．——908．-——介入放射学杂志2013年11月第22卷第11期JlnterventRadiol2013．V01．22．No．11·肿瘤介人Tumorintervention·经肝动脉化疗栓塞联合射频消融治疗肝细胞癌疗效荟萃分析赵松，陈学春，龙清云，张晓龙【摘要】目的探讨经肝动脉化疗栓塞(TACE)联合射频消融(RFA)与单独TACE或RFA对肝细胞癌(HCC)治疗的临床疗效比较。方法通过计算机检索或手工收集近期国内外关于TACE联合RFA疗法与TACE或RFA单独治疗HCC效果对比的文献

2、，对符合分析条件的21篇文献录入分析，重点比较患者术后生存率及复发率。结果与单独治疗组相比，联合治疗组1、2、3年生存率高，肿瘤复发率低，组间差异均有统计学意义(P<0．01)。数据敏感性分析显示，联合组无论1、2、3年生存率还是复发率均优于TACE或RFA组(P<0．01)。联合组1年生存率及局部复发率优于RFA组，且差异有统计学意义(P<0．05)，而2年生存率组问差异无统计学意义(P：0．05)。结论TACE联合RFA对于HCC治疗效果要优于TACE或RFA单独治疗，可有效提高患者生存期及

3、降低肿瘤复发率。【关键词】肝细胞癌；经肝动脉化疗栓塞；射频消融；荟萃分析中图分类号：R735．7文献标志码：A文章编号：1008—794X(2013)一11—0908—07Transcatheterarterialncombinedwithradiofrequencyablationforthetreatmentofhepatocellularcarcinoma：asystematicreviewandMetaanalysisZHA0Song，CHENXue—chun，LONGQing—yun，

4、ZHANGXiao—long．DepartmentofInterventionalRadiology，ZhongnauHospira!，WuhanUniversity，Wuhan，HubeiProvince430071，ChinaCorrespondingauthor：LONGQing—yun，E—mail：longqy2OO5Co~ahoo．com．cn【Abstract】0bjectiveTocomparetheclinicaleficacyoftranscatheterarterialch

5、emoembolization(TACE)combinedwithradiofrequencyablation(RFA)withthatofpureTACEorpureRFAintreatinghepatocellularcarcinoma(HCC)．MethodsThemedicalliteraturesrecentlypublishedathomeandabroadconcerningtheclinicalresultsofTACE+RFA，simpleTACEandsimpleRFAint

6、reatingHCCwerecollectedthroughelectronicormanualsearching．Atotalof21academicpaperswereenrolledinthisstudy．Thepostoperativesurvivalrateandrecurrencewereanalyzedandcomparedbetweendifferenttherapies．ResultsThe1一year，2-yearand3-yearsurvivalratesofTACE+RF

7、AcombinationgroupweresignificantlyhigherthanthoseofsimpleTACEgroupandsimpleRFAgroup(P<0．01)．Besides，therecurrencerateofTACE+RFAcombinationgroupwassignificantlylowerthanthatofsimpleTACEgroupandsimpleRFAgroup(P<0．01)．Analysisofdatasensitivityshowedthat

8、1一year，2-yearand3一yearsurvivalratesaswellastherecurencerateofTACE+RFAcombinationgroupweresuperiortothoseofTACEsubgroup(P