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时间:2020-05-14
《巨细胞病毒肝炎患儿合并心肌损伤的临床特点分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·20·中国实用医药2015年4月第l0卷第1l期ChinaPracMed,Apr2015,Vo1.10,N0.11巨细胞病毒肝炎患儿合并心肌损伤的临床特点分析汤昔康李汝霞【摘要】目的探讨巨细胞病毒(CMV)肝炎患儿合并心肌损伤的心电图及心肌酶谱变化,为临床诊治提供一定的依据。方法48例CMV肝炎患儿以入院时未予治疗前血CMV—DNA拷贝数≤1×104为组I(25例),>1X104为组Ⅱ(23例),同时选择同期行体检的35例健康婴儿作为正常组,分析三组婴儿心电图及心肌酶谱变化。结果48例CMV肝
2、炎患儿中合并心肌损伤35例,占72.9%。心电图异常l5例,分别为窦性心动过速11例,sT—T改变3例,房性早搏1例。组I、组Ⅱ患儿治疗前谷草转氨酶(AsT)、肌酸激酶(CK)、同工酶(CK—MB)、乳酸脱氢酶(LDH)均较正常组明显升高,差异有统计学意义(P3、无统计学意义(P>0.05)。结论CMV肝炎患儿易发生心肌损伤,病毒负荷越大,心肌损伤越重;其心电图改变多为非特异性,可通过CK—MB等心肌酶检测早期发现。给予及时治疗,心肌损伤绝大部分可恢复正常。【关键词】巨细胞病毒肝炎;心肌损伤;心电图;心肌酶谱DOI:10.14163~.enki11-5547/r.2015.11.010Analysisofclinicalcharacteristicsofchildrenofcytomegalovirushepatitiscomplicatedwithmy4、ocardialdamageTANGXi-kang,LIRu-xia.Sunrat-senMemorialHospitalofSunrat-senUniversity,Guangzhou510120,China【Abstract】ObjectiveToinvestigatethechangesofelectrocardiogramandmyocardiumenzymograminchildrenofcytomegalovirus(CMV)hepatitiscomplicatedwithmyoca5、rdialdamage,SOastoprovidereferenceforclinicaldiagnosisandtreatment.MethodsAtotalof48childrenwithCMVhepatitisweredividedintogroup1withCMV—DNAcopynumber≤1×10f25cases1andgroupII>1X104(23cases).The35healthychildrenatthesameperiodwereinthecontrolgroup.Cha6、ngesofelectrocardiogramandmyocardiumenzymograminthethreegroupswereanalyzed.ResultsAmongthe48childrenofCMVhepatitis,therewere35casescomplicatedwithmyocardialdamage,accountingfor72.9%.In15caseswithelectrocardiographicabnormality,therewerel1caseswithnod7、altachycardia,3caseswithST—Tchange,and1casewithatrialprematurebeats.GroupIandgroupⅡhadobviouslyincreasedaspartatetransaminase(AST),creatinekinase(CK),creatinekinase—MB(CK—MB),lactatedehydrogenase(LDH)thanthecontrolgroupbeforetreatment,andthediference8、hadstatisticalsignificance(P
3、无统计学意义(P>0.05)。结论CMV肝炎患儿易发生心肌损伤,病毒负荷越大,心肌损伤越重;其心电图改变多为非特异性,可通过CK—MB等心肌酶检测早期发现。给予及时治疗,心肌损伤绝大部分可恢复正常。【关键词】巨细胞病毒肝炎;心肌损伤;心电图;心肌酶谱DOI:10.14163~.enki11-5547/r.2015.11.010Analysisofclinicalcharacteristicsofchildrenofcytomegalovirushepatitiscomplicatedwithmy
4、ocardialdamageTANGXi-kang,LIRu-xia.Sunrat-senMemorialHospitalofSunrat-senUniversity,Guangzhou510120,China【Abstract】ObjectiveToinvestigatethechangesofelectrocardiogramandmyocardiumenzymograminchildrenofcytomegalovirus(CMV)hepatitiscomplicatedwithmyoca
5、rdialdamage,SOastoprovidereferenceforclinicaldiagnosisandtreatment.MethodsAtotalof48childrenwithCMVhepatitisweredividedintogroup1withCMV—DNAcopynumber≤1×10f25cases1andgroupII>1X104(23cases).The35healthychildrenatthesameperiodwereinthecontrolgroup.Cha
6、ngesofelectrocardiogramandmyocardiumenzymograminthethreegroupswereanalyzed.ResultsAmongthe48childrenofCMVhepatitis,therewere35casescomplicatedwithmyocardialdamage,accountingfor72.9%.In15caseswithelectrocardiographicabnormality,therewerel1caseswithnod
7、altachycardia,3caseswithST—Tchange,and1casewithatrialprematurebeats.GroupIandgroupⅡhadobviouslyincreasedaspartatetransaminase(AST),creatinekinase(CK),creatinekinase—MB(CK—MB),lactatedehydrogenase(LDH)thanthecontrolgroupbeforetreatment,andthediference
8、hadstatisticalsignificance(P
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