干扰素治疗慢性丙型肝炎患者所致视网膜病变的特征性分析-论文.pdf

《干扰素治疗慢性丙型肝炎患者所致视网膜病变的特征性分析-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、22·临床论著·干扰素治疗慢性丙型肝炎患者所致视网膜病变的特征性分析毛菲菲孙挥宇李丹游启生【摘要】目的观察使用干扰素治疗的慢性丙型肝炎(HCV)患者出现视网膜病变的特征。方法接受干扰素治疗后出现视网膜病变的患者共24例纳入研究。所有患者均进行矫正视力、裂隙灯显微镜、散瞳问接检眼镜、眼底彩色照相检查。眼底检查由具有丰富经验的眼底病医生完成。观察所有患者的眼底病变特征。结果本研究24例患者中男性16例，女性8例，男女比例为2：1；年龄21～78岁，平均年龄(48士14)岁。24例患者中有35只眼眼底异常，双眼发病13例，单眼发病l1例。12例患者使用后出现视物

2、模糊。眼底检查中：35只患眼中17例23只眼，占患眼的65．7％；眼底表现为单纯棉绒斑，单纯视网膜出血2例2只眼，占忠眼的5．7％；棉绒斑合并视网膜出血8例10只眼，占患眼的28．6％。棉绒斑及出血多位于视盘旁颞上或颞下血管附近，少数可散布于全后极部血管旁；其出血部位多位于棉绒斑旁，表现为后极部火焰状、点状出血或Roth斑。结论干扰素所致眼底视网膜病变最常见的特征为棉绒斑，使用后建议定期随访。【关键词】视网膜病变；棉绒斑；慢性丙型肝炎；干扰素Characteristicanalysisofretinopathyassociatedwithinterfero

3、ntherapyinpatientswithchronichepatitisCMAOFeifei，SUNHuiyu，LIDan，YOUQisheng．*DepartmentofOphthalmology,BeijingDitanHospital,CapitalMedicalUniversity,Beij'ing100015,ChinaCorrespondingauthor．"SUNHuiyu，Email：sunhuiyu123@126com[Abstract]ObjectiveToobserveandanalyzetheretinopathyassocia

4、tedwithinterferontherapyinpatientswithchronichepatitisC(CHC)．MethodsTwenty—fourCHCpatients(including16menand8women)withretinopathywerecollected．Thedetailedocularexaminationsincludingcorrectedvisualacuity,intraocularpressure，slitlampmicroscope，indirectophthalmoscopeandcolorfundusph

5、otographyweredonein24patients．Fundusexaminationswerecarriedoutbyexperiencedocularfundusdoctorsandtheretinopathycharacteristicswererecorded．ResultsTheageofthepatientsvariedfrom21to78years，withtheaverageof48士14yearsold．Totalof35eyeswerefoundwithretinopathyin24patientsamongwhich13pat

6、ientswerefoundwithbilateralretinopathyand11patientswithunilateralretinopathy．Blurredvisionwerefoundin12patients．Cotton—woolspots(CWS)withoutretinalhemorrhage，mostlylocatedclosetotemporalperipapillaryvessels，werefoundin23eyes(65．7％)of17patients．Twoeyes(5．7％)of2caseswerefoundtohavef

7、lamingorspottinghemorrhagelocatedinposteriorpole．Teneyes(28．6％)of8caseswerefoundtohaveretinalhemorhagemostlylocatednearCWS．ConclusionsCWSarethemostcommonocularlesionsinretinopathyassociatedwithinterferontherapyinpatientswithCHC．Thepatientsshouldbefollowedupaftertreatment．[Keywords

8、]Retinopathy；Cotton—woolspots；Chr