抗病毒治疗对慢乙肝相关致癌因素的干预研究-论文.pdf

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1、现代生物医学进展www．shengwuyixue．comProgressinModernBiome~cineVoL14NOg．0JUL2014·3909·doi：10．132418．cnki．pmb．2014．20．029TheStudyofInterventionOfAntiviralTherapytoChronicHepatitisB．RelatedCarcinogensCHENFe，WANGZhe-linge,GAOR砸，L1UZhong-jingeflQingdaoUniversRy；Qing

2、dao,Shandong,266021，China；2QingdaoInfectiousDiseasesHospital,Qingdao,Shandong,266033,C盈血】a】ABSTRACTObjective：Toinvestigatetheinterventionofantiviralther~yontheriskfactorsofchronichepatitisB-relatedhepatoc-ellularcarcinoma．Methods：249hospitalizedcasesofh

3、epatocellularcarcinomainQingdaoInfectiousDiseasesHospitalfromFebruary2010toJune2012wereretrospectivelyanalyzed．Therelevantdatarecordedonthequestionnairepreparedbytheunifiedwasusedtocomparethedistributionofvariousfactorsbetweenantiviraltreatmentgroupandn

4、o—antiviraltreatmentgroup．Results：ThediferencesoftimeofHBVinfectionandthatofcirrhosisbeforediagnosedwithHCC，andHBVDNAlevelbetweenantiviraltreatmentgroupandno-antiviraltreatmentgroupwerestatisticallysignificant，P<0．05；HBVinfectionpatterns，AFP，CEAhadnosig

5、nificantdiferencesbetweenthetwogroups．Diferencesofrelatedindicatorsofliverfunctionwerestatisticallysignificant．Conclusions：AntiviralthempycouldsignificantlyreducethepercentageofthecarcinogenicfactorsassociatedwithchronichepatitisBinpatients，anditcanefec

6、tivelyinhibitthereplicationofHBVDNA，whichmaybereducetheincidenceofHBV-relatedHCC．Keywords：Hepatocellularcarcinoma；ChronichepatitisB：Riskfactors；AntiviraltherapyChineseLibraryClassifieation(CLC)：R512．6，R735．7Documentcode：AArticleID：1673-6273(2014)20-3909

7、·-05metabolicandotherreasonscirhosis，thecancerofotherpartsandIntroductionmetastaticlivercanceralsowereremoved．Thesubjectsaredivid-ChronichepatitisBvirus(HBV)infectionisthemainreasonedintoantiviraltreatmentgroupandno-antiviraltreatmentgroupofhepatocellul

8、arcarcinoma(HCC)inChina．ThemajorityofHCCbasedthatiftheytooktheoralnucleosideantiviraldrugs．isevolvedfromcirrhosisafterHBVinfectionB21．andtherelevant1．2ContentsoftheobservationinformationshowsthathighHBVDNAlevelistheabsoluteriskAl