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时间:2020-05-04
《CT能谱成像鉴别肝癌和肝脏局灶性结节增生的临床价值-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、实用肝脏病杂志2013年l0月第16卷第5期JClinHepotol,Oct.2013.Vo1.16No.5·411··肝肿瘤·CT能谱成像鉴别肝癌和肝脏局灶性结节增生的临床价值郑盛唐映梅杨晋辉尤丽英【摘要】目的探讨CT能谱成像在鉴别肝癌和肝局灶性结节增生(FNH)中的应用价值。方法回顾性分析46例肝脏占位性病变患者(肝癌32例,FNH14例)行64层CT双期能谱扫描结果。测量病灶、正常肝组织和腹主动脉的能谱参数,对比分析两种占位性病变间不同能量水平下病灶一肝脏对比噪声~(CNR)、标准化碘浓度(NIC
2、)、病灶与正常肝组织碘浓度比值(LNR)及病灶动脉期和门静脉期碘浓度的差异(ICD)等。结果除部分能量点外,肝癌和FNH在不同能量水平下的CNR随着单光子能量的增加而减小。肝癌和FNH的动脉期最佳CNR分别为3.64-1.1和8.3±2.7,门静脉期最佳CNR分别为1.8±0.3和1.1±0.2;肝癌和FNH动脉期NIC分别为0.3±0.1和0.4±O.1,门静脉期NIC分别为0.5±0.1和0.9±0-2;动脉期LNR分别为3.0±0.5和6.2±1.0,门静脉期LNR分别为1.0±0.1和1.2±0
3、.3;动脉期和门静脉期ICD值分别为0.4±0.1g/L和1.2±0.3gm。肝癌动脉期和门静脉期的NIC、LNR和ICD值均低于FNH,差异均有统计学意义(NIC比较,t值分别为一3.196、一6.518;LNR比较,t值分别为一12.911、一3.260;ICD比较,t值为一2.754,P均4、层摄影术;能谱成像;鉴别诊断doi:10.3969/j.issn.1672-5069.2013.05.009SpectralCTimagingindiferentialdiagnosisofhepatocellularcarcinomaandfocalnodularhyperplasiaZhengSheng,TangYingmei,YangJinhui,eta1.DepartmentofGastroenterology,ThirdProvincialPeople’sHospital,Kunming6505、011,China【Abstract】0bjecfiveToassesstheclinicalvalueofspectralCTimagingindifferentialdiagnosisofhepatocellularcarcinoma(HCC)andfocalnodularhyperplasia(FNH).MethodsSerialspectralimagesfromforty—sixpatientswithhepaticmass(32withHCCand14withFNH)receiveddual6、-phaseCTspectralimagingwereanalyzedretrospectively.Thespectralparametersofthemass,thenormalhepatictissuesandtheaortawereobtained.Thecontrast—to—noiseratio(CNR)ofmass-to-liverunderdifferentenergylevels,thenormalizediodineconcentration(NIC)。themass—to—live7、riodineconcentrationratio(LNR)andtheiodineconcentrationdifference(ICD)betweenthearterialphaseandtheportalveinphasewerecalculated.Allthemeasurementswereanalyzedwithtwo-samplettestandROCcurve.ResultsTheCNRofHCCandFNHunderdifferentenergydecreasedwithincreas8、edsinglephotonenergyexceptforsomeenergypoints.Atthea~erialphase.theoptimalCNRwas3.6±1.1forHCCand8.3±2.7forFNH,andinHCC,theNICandLNRwere0.3±0.1and3.0±0.5,respectively,whichweresignificantlylowerthanthoseinFNH(NICwas0.4~0.1,
4、层摄影术;能谱成像;鉴别诊断doi:10.3969/j.issn.1672-5069.2013.05.009SpectralCTimagingindiferentialdiagnosisofhepatocellularcarcinomaandfocalnodularhyperplasiaZhengSheng,TangYingmei,YangJinhui,eta1.DepartmentofGastroenterology,ThirdProvincialPeople’sHospital,Kunming650
5、011,China【Abstract】0bjecfiveToassesstheclinicalvalueofspectralCTimagingindifferentialdiagnosisofhepatocellularcarcinoma(HCC)andfocalnodularhyperplasia(FNH).MethodsSerialspectralimagesfromforty—sixpatientswithhepaticmass(32withHCCand14withFNH)receiveddual
6、-phaseCTspectralimagingwereanalyzedretrospectively.Thespectralparametersofthemass,thenormalhepatictissuesandtheaortawereobtained.Thecontrast—to—noiseratio(CNR)ofmass-to-liverunderdifferentenergylevels,thenormalizediodineconcentration(NIC)。themass—to—live
7、riodineconcentrationratio(LNR)andtheiodineconcentrationdifference(ICD)betweenthearterialphaseandtheportalveinphasewerecalculated.Allthemeasurementswereanalyzedwithtwo-samplettestandROCcurve.ResultsTheCNRofHCCandFNHunderdifferentenergydecreasedwithincreas
8、edsinglephotonenergyexceptforsomeenergypoints.Atthea~erialphase.theoptimalCNRwas3.6±1.1forHCCand8.3±2.7forFNH,andinHCC,theNICandLNRwere0.3±0.1and3.0±0.5,respectively,whichweresignificantlylowerthanthoseinFNH(NICwas0.4~0.1,
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