右美托咪定滴鼻对小儿七氟烷麻醉术前焦虑和术后躁动的影响.pdf

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1、工苏医药2012年4月第38卷第7期JiangsuMedJ，ADri12012，Vol38，No．7·83l·论著●右美托咪定滴鼻对小儿七氟烷麻醉术前焦虑和术后躁动的影响高燕春谢言虎柴小青侯冠峰方才【摘要】目的观察右美托咪定(DM)滴鼻对d,JL术前焦虑和术后躁动的影响。方法将60例1—4岁疝气手术&JL随机均分为三组。七氟烷麻醉诱导前30min，11、Ⅲ组分别予以DM0．5／和1ug／kg滴鼻，I组滴生理盐水0．4ml对照。连续监测BP、HR、SpO2、PE1一c()2。观察患儿人事的镇静情绪评分、诱导时间、麻醉时间、苏醒时间、不良反应及术后患儿的躁动评分。结果『『I组患儿术前镇静满意率明显

2、高于I组和Ⅱ组(45vs．10和15)(P<0．05)。与I组、Ⅱ组比较，『I1组躁动评分和诱导时间明显降低(P<0．01)。三组间苏醒时间差异无统计学意义(P>o．05)。结论诱导前应用DM1#g／kg滴鼻可有效改善d,JL术前焦虑情绪，缩短七氟烷麻醉诱导时问，降低苏醒期躁动的发生率，且不延长苏醒时间。【关键词】右美托咪定；焦虑；苏醒期躁动；七氟烷；d,JL【中图分类号】R614【文献标识码】A【文章编号】0253～3685(2012)07083l一()3Effectsofintranasalde~anedetomidineaspremedicationonpreoperativeanxie

3、tyandemergencedeliriumaftersevofluraneanesthesiainchildrenGAOYanchun，XIEYanhu，CHAIXiaoqing，ela1．DepartmentofAnesthesiology，AnhuiProvincialhospital，Hefei230001，CHlNA[Abstract]ObjectiveToobservetheeffectsofintranasa1dexmedetomidine(I)M)asprdmedicationonpreoperativeanxietyandemergencedeliriumaftersevof

4、luraneanesthesiainchildren．MethodsSixtyof1-4year-oldchildrenundergoingherniasurgeryundersevofluraneanesthesiawereequallyrandomizedintotreegroupsofA(intranasalDM0．5Fg／kg)，B(intranasalDM1／~g／kg)andC(intranasalnoiTna1saline0．4m1)．Sevofluraneanesthesiawasinducedat30minutesafterintranasaladministration．B

5、P．HRandSr)02weremonitoredduringtheoperation．Thesadationscores，thetimesforinduction。anesthesiaandawaken，adversereactions，agitationscoreswererecorded．ResultsThesatisfactionrateforpreanesthesiasedationwassignificantlyhigheringroupBthanthatingroupsofAandC(45vs．10and15)(P<0．05)．Thetimeforinductionwasshor

6、ter，andtheagitationscorewasloweringrotIpBthanthaoseingroupsofAandC(P~0．01)．Therewasnosignificantdifferenceinthetimeforawakeningamongthreegroups(P>0．05)．ConclusionIntranasalDM1~g／kgaspremedicationiseffectiveforreducinganxietyandtheincidenceofemergencedeliriumwithoutdelayingtheawakeningtime．[Keywards]

7、Dexmedetomidine；Anxiety；Emergencedelirium；Sevoflurane；ChildrenJJiangsuMedJ，April2012，38(7)：831．833．J作者单位：230001安徽医科大学附属省立医院麻醉科通讯作者：方才E-mail：doctor．fc@yahoo．com．cn使EGFR基因扩增或翻译及翻译后的调节异常而humancoloncarcin